DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and itr1

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_593858.2	Gene:	itr1 / 2543145	PomBaseID:	SPAC4F8.15	Length:	575	Species:	Schizosaccharomyces pombe

Alignment Length:	502	Identity:	112/502 - (22%)
Similarity:	226/502 - (45%)	Gaps:	73/502 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 MVFLGNSGVLGSGMVVSMPAVTLNQLHDETQPFWLNKDESSWFASIQNMACPLGGLLVSYFLDRI 112
            ::|..::||:...:||...::..::|.:..:.|         ..|..::...|||::.....|..
pombe    99 LLFGYDTGVISGALVVIGTSLGGHELTNGGKEF---------ITSATSLGALLGGIIAGALADFF 154

  Fly   113 GRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRCFGGIMIGMFVSPVGVYSAEISLPK 177
            |||..|.:.::|.::|.|:.||:  |.     .:.|::||...|..:|:....:.:|.:||:..|
pombe   155 GRKPVIAIASIIIIVGSIVQVTA--HH-----LWHMIVGRFVIGWGVGIASLIIPLYLSEIAPSK 212

  Fly   178 IRGRLILGTSLGLASGILLMYCLGYFIRH---NIQLIFGIS---CCYQLAATLLVFPMPESPSWL 236
            |||||::...|.:.:|.::.|.:.....|   ..:.:.|::   ..:||   .::..:||||..|
pombe   213 IRGRLVIIYVLLITAGQVIAYGIDTAFEHVHNGWRWMVGLAMVPAAFQL---FILIWLPESPRLL 274

  Fly   237 LTRGKEERARKSLRYFRGLPKKEVDYVPEFEAELAHMKE-LAD---ASNTTAAGESLSQMIHRPE 297
            :   |:||::::......:......|  |.:.:|..::| :.|   .|......::..::...|.
pombe   275 V---KKERSQEAYNTLARIYPTAHPY--EIKTKLYLIQEGVRDPFSGSRWQKIVKTFKELYFNPS 334

  Fly   298 VYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQAGVTIDPVLVAVMLGVARIITTLFMSGIFEKW 362
            .::.:::.......||..|...::.::..|.:..|.. :|....:::.....:.|:...|:.:.:
pombe   335 NFRALILACGLQAMQQLSGFNSLMYFSSTIFEVVGFN-NPTATGLIIAATNFVFTIVAFGVIDFF 398

  Fly   363 GRKPSGIFSATGMGACMLLLA----------GGNWFPDTLGTLHWLPVACIVAHIVF---STMGM 414
            ||:...:.:..||.|.:::.|          .||:   |.|..:...:..:::.||:   ...|:
pombe   399 GRRILLLLTVWGMIAALIVCAVAFHFLPKDENGNY---TSGQSNAWAIVVLISMIVYVASYASGL 460

  Fly   415 LTLPFFMISEVFPQRARGSASGIA--------IFFGMILAFIMLKIYPNMEAALGTANLFAFYAG 471
            ..|| :..||:||...||..:|::        :..|.....:|.:|.|.     ||   ||.|.|
pombe   461 GNLP-WQQSELFPMSVRGLGTGMSTAVNWAGNLGIGASFLTLMSEITPT-----GT---FALYGG 516

  Fly   472 ISFLAAAFIGVF--VPETRGRTLEELEERWQTGKFSRRLTIVNLKDV 516
            :.||  .::|..  .|:....|:||:.|..:.| |..|.::.:||.|
pombe   517 LCFL--GWLGALFCYPDLTDYTIEEIGELLKHG-FGVRESMRHLKRV 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	100/461 (22%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	99/460 (22%)
itr1	NP_593858.2	Sugar_tr	90..544	CDD:278511	106/483 (22%)
itr1	NP_593858.2	MFS	92..529	CDD:119392	101/468 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X729
TreeFam	0	0.000	Not matched by this tool.
	2	1.900