DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_033230.2	Gene:	Slc2a4 / 20528	MGIID:	95758	Length:	509	Species:	Mus musculus

Alignment Length:	486	Identity:	124/486 - (25%)
Similarity:	205/486 - (42%)	Gaps:	69/486 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LMVFLGNSGVLGSGM------VVSMPAVTLNQLHDETQPFWLNKD-------------ESSWFAS 92
            |.||   |.||||..      |::.|...:.|.::.|   ||.:.             .:.|..|
Mouse    26 LAVF---SAVLGSLQFGYNIGVINAPQKVIEQSYNAT---WLGRQGPGGPDSIPQGTLTTLWALS 84

  Fly    93 IQNMACPLGGLLVSYFLDRI----GRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRC 153
            :...:  :||::.|:.:..|    |||..:|..|::.::|..|:..    ::....|..::|||.
Mouse    85 VAIFS--VGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGL----ANAAASYEILILGRF 143

  Fly   154 FGGIMIGMFVSPVGVYSAEISLPKIRGRLILGTSLGLASGILLMYCLGYFIRHNIQLIFGISCCY 218
            ..|...|:....|.:|..||:...:||.|.....|.:..|||:...||      ::.:.|.:..:
Mouse   144 LIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLG------LESMLGTATLW 202

  Fly   219 QLAATLLVFP----------MPESPSWL-LTRGKEERARKSLRYFRGLPKKEVDYVPEFEAELAH 272
            .|...|.|.|          .||||.:| :.|..|..|||||:...|...     |.:..|||..
Mouse   203 PLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGWAD-----VSDALAELKD 262

  Fly   273 MKELADASNTTAAGESLSQMIHR-PEVYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQAGVTID 336
            .|...:.....:..:.|....|| |.:...||.::     ||..|:..:..|:..|.:.|||. .
Mouse   263 EKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLS-----QQLSGINAVFYYSTSIFESAGVG-Q 321

  Fly   337 PVLVAVMLGVARIITTLFMSGIFEKWGRKPSGIFSATGMGACMLLLAGGNWFPDTLGTLHWLPVA 401
            |....:..||...:.||....:.|:.||:...:....||..|.:|:.......:.:..:.::.:.
Mouse   322 PAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIV 386

  Fly   402 CIVAHIVFSTMGMLTLPFFMISEVFPQRARGSASGIAIFFGMILAFIMLKIYPNMEAALGTANLF 466
            .|...:.|..:|...:|:|:::|:|.|..|.:|..:|.|......||:...:..:..|:|.   :
Mouse   387 AIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGP---Y 448

  Fly   467 AFYAGISFLAAAFIGVF--VPETRGRTLEEL 495
            .|......|...||..|  ||||||||.:::
Mouse   449 VFLLFAVLLLGFFIFTFLKVPETRGRTFDQI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	112/465 (24%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	114/458 (25%)
Slc2a4	NP_033230.2	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	123/485 (25%)
		MFS	78..447	CDD:119392	96/391 (25%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840