back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and SLC2A6

DIOPT Version :10

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens

Alignment Length:	525	Identity:	145/525 - (27%)
Similarity:	237/525 - (45%)	Gaps:	58/525 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KPTVVAKDTTKDSHAKEKPLGEG---RLAVLRQELMVFLGN-SGVLGS-----GMVVSMPAVTLN 71
            :|.:.|:....|:..::.|...|   |:..| |...|||.. :.|||:     .:|.:.|.:.
Human     3 EPLLGAEGPDYDTFPEKPPPSPGDRARVGTL-QNKRVFLATFAAVLGNFSFGYALVYTSPVIP-- 64

  Fly    72 QLHDETQP-FWLNKDESSWFASIQNMACPLGGLLVSYFLDRIGRKHTILLTNLIGLIGWILLVTS 135
            .|.....| ..|.|.::|||.|:..:....|||......|.:|||.:|:.:.:....|:.|:..:
Human    65 ALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGA 129

  Fly   136 FMHSDRDMIYYQMLLGRCFGGIMIGMFVSPVGVYSAEISLPKIRGRLILGTSLGLASGILLMYCL 200
              |.     .:.:||||...|...|:..:.:.||.:||:.|.:||.|.....|....|.|.:|.|
Human   130 --HG-----LWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYAL 187

  Fly   201 GYFIRHNIQLIFGISCCYQLAATLLVFPMPESPSWLLTRGKEERARKSLRYFRGLPKKEVDYVPE 265
            |..:......:.|.:..  |...||:..||.||.:||:||::|.|.::|.:.||   .:||...|
Human   188 GLLLPWRWLAVAGEAPV--LIMILLLSFMPNSPRFLLSRGRDEEALRALAWLRG---TDVDVHWE 247

  Fly   266 FEAELAHMKELADASNTTAAGESLSQMIHRPEVYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQ 330
            ||       ::.|.....::..|.:: ...|.|.:|:.:.......||..|:..|:||...|...
Human   248 FE-------QIQDNVRRQSSRVSWAE-ARAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDS 304

  Fly   331 AGVTIDPVLVAVMLGVARIITTLFMSGIFEKWGRKPSGIFSATGMGACMLLL------------- 382
            ..|.:.|...|.::|..|:::.|..:...:..|||.....||..|.|..|.|
Human   305 TAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSP 369

  Fly   383 ---AG---GNW------FPDTLGTLHWLPVACIVAHIVFSTMGMLTLPFFMISEVFPQRARGSAS 435
               ||   .:|      .....|.|..:|:...:..|:...:|...:.:.::|||.|.||||.||
Human   370 NSTAGLESESWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVAS 434

  Fly   436 GIAIFFGMILAFIMLKIYPNMEAALGTANLFAFYAGISFLAAAFIGVFVPETRGRTLEELEERWQ 500
            |:.:....:.||::.|.:..:.:..|....|.|:|.|..::..|.|..||||:||:||::|..::
Human   435 GLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFFR 499

  Fly   501 TGKFS 505
            ||:.|
Human   500 TGRRS 504

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.