DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4593 and CCDC25

DIOPT Version :9

Sequence 1:	NP_001284975.1	Gene:	CG4593 / 31649	FlyBaseID:	FBgn0029929	Length:	209	Species:	Drosophila melanogaster
Sequence 2:	NP_060716.2	Gene:	CCDC25 / 55246	HGNCID:	25591	Length:	208	Species:	Homo sapiens

Alignment Length:	211	Identity:	119/211 - (56%)
Similarity:	159/211 - (75%)	Gaps:	5/211 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFYFKSNVVQPPA-MLYMGRDKHENEELIRWGWPEDVWFHVHDLSSAHVYLRLRKGQTIDDIPT 64
            |||||.|:.|...| .:|||:||:|||:||:.|||||:||||..||||||||||.||:.|:|||.
Human     1 MVFYFTSSSVNSSAYTIYMGKDKYENEDLIKHGWPEDIWFHVDKLSSAHVYLRLHKGENIEDIPK 65

  Fly    65 DVLVDAAQLCKANSIQGNKVNNLEVVYTMWENLKKTPDMEPGQVAYHNEKAVRRIRLEKRINEIV 129
            :||:|.|.|.|||||||.|:||:.||||.|.|||||.||:.||:.:|.:|.|:.:.:||::|||:
Human    66 EVLMDCAHLVKANSIQGCKMNNVNVVYTPWSNLKKTADMDVGQIGFHRQKDVKIVTVEKKVNEIL 130

  Fly   130 NRLNRTKTEEEHPDFRGLREARDAAERQDQK-KIQRERREQEKEAAKQRELEAELRSYASLQKSE 193
            |||.:||. |..||....:|.||..||.::| :||..::.:::|..|:||:: |||||:||.|.|
Human   131 NRLEKTKV-ERFPDLAAEKECRDREERNEKKAQIQEMKKREKEEMKKKREMD-ELRSYSSLMKVE 193

  Fly   194 NMRTNYDAGNESDDFM 209
            ||.:|.| ||:||:||
Human   194 NMSSNQD-GNDSDEFM 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4593	NP_001284975.1	DUF814	7..99	CDD:283353	60/92 (65%)
CG4593	NP_001284975.1	DUF4337	<123..>182	CDD:290935	24/59 (41%)
CCDC25	NP_060716.2	DUF814	1..112	CDD:368552	72/110 (65%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:32528174	21..25		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..208		29/61 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159365
Domainoid	1	1.000	157	1.000	Domainoid score	I4173
eggNOG	1	0.900	-	-		E1_KOG3272
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6645
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3392
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53870
OrthoDB	1	1.010	-	-		D1380409at2759
OrthoFinder	1	1.000	-	-		FOG0004988
OrthoInspector	1	1.000	-	-		oto89123
orthoMCL	1	0.900	-	-		OOG6_102835
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2167
SonicParanoid	1	1.000	-	-		X3521
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.700