DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3032 and ZNF160

DIOPT Version :9

Sequence 1:	NP_001284974.1	Gene:	CG3032 / 31648	FlyBaseID:	FBgn0029928	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	484	Identity:	127/484 - (26%)
Similarity:	200/484 - (41%)	Gaps:	120/484 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QLEK--------EPLKTELQSDEIPISQELQQLLNINLSQDVENQDADQQWLPNELCLECRSAV- 75
            |:||        .||:....|.:...|::..:|.:.:|.  .:.:.|:....|.: |.||..|.
Human   206 QVEKSTNNGSSVSPLQQIPSSVQTHRSKKYHELNHFSLL--TQRRKANSCGKPYK-CNECGKAFT 267

  Fly    76 --QNFEKFRR--------KADECRKQLLEMLKKDPREPTF---------EVVYDGRE-------- 113
              .|....||        |..||.|             ||         :|::.|.:
Human   268 QNSNLTSHRRIHSGEKPYKCSECGK-------------TFTVRSNLTIHQVIHTGEKPYKCHECG 319

  Fly   114 ---------EDQESLHGLEPPEPAPDPDPIDEPAIKSDKSPRKSFRGSRN------------TLK 157
                     .....:|..|.|....:..              |:|||..|            ..|
Human   320 KVFRHNSYLATHRRIHTGEKPYKCNECG--------------KAFRGHSNLTTHQLIHTGEKPFK 370

  Fly   158 CSVCRRSFAHQITLAAHIRKVHEGSKRPFQCDQCEKAYSFMGGLYTHIREVHAPKERRHPCDQPG 222
            |:.|.:.|.....|.:|.| :|.|.| |::|::|.||:|....|..| :.:|. .|:.:.|::
Human   371 CNECGKLFTQNSHLISHWR-IHTGEK-PYKCNECGKAFSVRSSLAIH-QTIHT-GEKPYKCNE-- 429

  Fly   223 CERIYTSRIAMQKHKRLKHSPRDRDALKKFICEQCGASFNQSANLKYHLK-------------TK 274
            |.:::.....:.:|:|: |:..     |.:.|.:||.:|:..:||..|..             :|
Human   430 CGKVFRYNSYLGRHRRV-HTGE-----KPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSK 488

  Fly   275 HPTEDEVAA--REGGAGERHF-CDICQKEFHSRYTLKYHTLQQHEVQEELPHECQVCGRRMAKKF 336
            ..|::...|  |....||:.: |:.|.|.|..|.:|..|   |.....|.|::|..||:...:|.
Human   489 VFTQNSQLANHRRIHTGEKPYKCNECGKAFSVRSSLTTH---QAIHSGEKPYKCIECGKSFTQKS 550

  Fly   337 MLLQHMLMHSNDK-LPCEHCGRRFARRFELEAHVRAVHLKLKPFPCHHCPESFASRKTLRHHEYI 400
            .|..|..:||.:| ..|..||:.||:..:|..|.| ||...||:.|:.|..:|:.|.:|..|:.|
Human   551 HLRSHRGIHSGEKPYKCNECGKVFAQTSQLARHWR-VHTGEKPYKCNDCGRAFSDRSSLTFHQAI 614

  Fly   401 HTGEKPYICDTCGQAFRQQTCLKNHRKVH 429
            |||||||.|..||:.||..:.|..||::|
Human   615 HTGEKPYKCHECGKVFRHNSYLATHRRIH 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3032	NP_001284974.1	zf-AD	13..95	CDD:285071	22/93 (24%)
		C2H2 Zn finger	158..179	CDD:275368	6/20 (30%)
		C2H2 Zn finger	188..209	CDD:275368	7/20 (35%)
		C2H2 Zn finger	218..239	CDD:275368	3/20 (15%)
		C2H2 Zn finger	254..275	CDD:275368	7/33 (21%)
		C2H2 Zn finger	294..315	CDD:275368	7/20 (35%)
		C2H2 Zn finger	325..345	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523	7/22 (32%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		zf-H2C2_2	271..295	CDD:290200	8/36 (22%)
		C2H2 Zn finger	287..307	CDD:275368	6/32 (19%)
		zf-H2C2_2	299..324	CDD:290200	2/24 (8%)
		C2H2 Zn finger	315..335	CDD:275368	0/19 (0%)
		zf-H2C2_2	327..350	CDD:290200	4/36 (11%)
		C2H2 Zn finger	343..363	CDD:275368	5/33 (15%)
		zf-H2C2_2	355..380	CDD:290200	5/24 (21%)
		COG5048	367..810	CDD:227381	93/293 (32%)
		C2H2 Zn finger	371..391	CDD:275368	6/20 (30%)
		C2H2 Zn finger	399..419	CDD:275368	7/20 (35%)
		zf-H2C2_2	411..436	CDD:290200	6/28 (21%)
		C2H2 Zn finger	427..447	CDD:275368	4/22 (18%)
		zf-H2C2_2	439..463	CDD:290200	7/29 (24%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275368	4/19 (21%)
		zf-H2C2_2	496..519	CDD:290200	7/22 (32%)
		C2H2 Zn finger	511..531	CDD:275368	8/22 (36%)
		zf-H2C2_2	523..548	CDD:290200	8/27 (30%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		zf-H2C2_2	551..576	CDD:290200	9/24 (38%)
		C2H2 Zn finger	567..587	CDD:275368	8/20 (40%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		zf-H2C2_2	607..632	CDD:290200	14/24 (58%)
		C2H2 Zn finger	623..643	CDD:275368	8/19 (42%)
		zf-H2C2_2	635..659	CDD:290200	4/9 (44%)
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
		zf-H2C2_2	691..715	CDD:290200
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	719..744	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		zf-H2C2_2	747..770	CDD:290200
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930