DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3032 and ZNF347

DIOPT Version :9

Sequence 1:	NP_001284974.1	Gene:	CG3032 / 31648	FlyBaseID:	FBgn0029928	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001166145.1	Gene:	ZNF347 / 84671	HGNCID:	16447	Length:	840	Species:	Homo sapiens

Alignment Length:	486	Identity:	122/486 - (25%)
Similarity:	200/486 - (41%)	Gaps:	99/486 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ELCCTCLLQLEKEPLKTELQ--------------------SDEIPISQELQQ------------L 44
            :|....:|:..|||...|.|                    |.|..:...|.:            :
Human    54 DLSIISMLEQGKEPFTLESQVQIAGNPDGWEWIKAVITALSSEFVMKDLLHKGKSNTGEVFQTVM 118

  Fly    45 LNINLSQDVEN-QDADQQWLPNELCLECRSAVQNF----------------EKFRRKADE--CRK 90
            |....|||:|. ...:.|...:.|..:||.|..|:                |..:|.|..  .:.
Human   119 LERQESQDIEGCSFREVQKNTHGLEYQCRDAEGNYKGVLLTQEGNLTHGRDEHDKRDARNKLIKN 183

  Fly    91 QL-LEMLKKDPREPTFEVVYDGR-------EEDQESLHGLEPPEPAP--DPDPIDEPAIKSDKSP 145
            || |.:....|....|:  |:|:       |:...:...:.||:..|  ....|.:..:|...|.
Human   184 QLGLSLQSHLPELQLFQ--YEGKIYECNQVEKSFNNNSSVSPPQQMPYNVKTHISKKYLKDFISS 246

  Fly   146 RKSFRGSR-----NTLKCSVCRRSFAHQITLAAHIRKVHEGSKRPFQCDQCEKAYSFMGGLYTHI 205
            ....:|.:     :..|.:.|...|.....||:|.|.  ...::|::|.:|.||:.....|.||
Human   247 LLLTQGQKANNWGSPYKSNGCGMVFPQNSHLASHQRS--HTKEKPYKCYECGKAFRTRSNLTTH- 308

  Fly   206 REVHAPKERRHPCDQPGCERIYTSRIAMQKHKRLKHSPRDRDALKKFICEQCGASFNQSANLKYH 270
            :.:|. .|:|:.|::  |.::::....:.:|::: |:..     |.:.|.:||..|.|:::|..|
Human   309 QVIHT-GEKRYKCNE--CGKVFSRNSQLSQHQKI-HTGE-----KPYKCNECGKVFTQNSHLVRH 364

  Fly   271 LKTKHPTEDEVAAREGGAGERHF-CDICQKEFHSRYTLKYHTLQQHEVQEELPHECQVCGRRMAK 334
                         |....||:.: |:.|.|.|.:|.:|..|   |.....|.|::|..||:...:
Human   365 -------------RGIHTGEKPYKCNECGKAFRARSSLAIH---QATHSGEKPYKCNECGKVFTQ 413

  Fly   335 KFMLLQHMLMHSNDK-LPCEHCGRRFARRFELEAHVRAVHLKLKPFPCHHCPESFASRKTLRHHE 398
            ...|..|..:|:.:| ..|..||:.|..|..|..|: .:|...||:.||.|.:.|.....|..|:
Human   414 NSHLTNHWRIHTGEKPYKCNECGKAFGVRSSLAIHL-VIHTGEKPYKCHECGKVFRRNSHLARHQ 477

  Fly   399 YIHTGEKPYICDTCGQAFRQQTCLKNHRKVH 429
            .||||||||.|:.||:|||..:.|..|:.:|
Human   478 LIHTGEKPYKCNECGKAFRAHSNLTTHQVIH 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3032	NP_001284974.1	zf-AD	13..95	CDD:285071	27/133 (20%)
		C2H2 Zn finger	158..179	CDD:275368	6/20 (30%)
		C2H2 Zn finger	188..209	CDD:275368	7/20 (35%)
		C2H2 Zn finger	218..239	CDD:275368	3/20 (15%)
		C2H2 Zn finger	254..275	CDD:275368	7/20 (35%)
		C2H2 Zn finger	294..315	CDD:275368	7/20 (35%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
ZNF347	NP_001166145.1	KRAB	8..67	CDD:214630	3/12 (25%)
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	265..284	CDD:275368	6/20 (30%)
		COG5048	273..728	CDD:227381	80/265 (30%)
		zf-H2C2_2	276..301	CDD:290200	9/26 (35%)
		C2H2 Zn finger	292..312	CDD:275368	7/20 (35%)
		zf-H2C2_2	304..329	CDD:290200	8/28 (29%)
		C2H2 Zn finger	320..340	CDD:275368	3/22 (14%)
		zf-H2C2_2	333..357	CDD:290200	7/29 (24%)
		C2H2 Zn finger	348..368	CDD:275368	8/32 (25%)
		zf-H2C2_2	360..383	CDD:290200	8/35 (23%)
		C2H2 Zn finger	376..396	CDD:275368	8/22 (36%)
		zf-H2C2_2	388..413	CDD:290200	8/27 (30%)
		C2H2 Zn finger	404..424	CDD:275368	5/19 (26%)
		zf-H2C2_2	416..439	CDD:290200	7/22 (32%)
		C2H2 Zn finger	432..452	CDD:275368	7/20 (35%)
		zf-H2C2_2	444..469	CDD:290200	9/25 (36%)
		zf-C2H2	458..480	CDD:278523	6/21 (29%)
		C2H2 Zn finger	460..480	CDD:275368	6/19 (32%)
		zf-H2C2_2	472..495	CDD:290200	13/22 (59%)
		C2H2 Zn finger	488..508	CDD:275368	8/19 (42%)
		zf-H2C2_2	500..525	CDD:290200	3/9 (33%)
		C2H2 Zn finger	516..536	CDD:275368
		zf-H2C2_2	528..552	CDD:290200
		C2H2 Zn finger	544..564	CDD:275368
		zf-H2C2_2	556..581	CDD:290200
		C2H2 Zn finger	572..592	CDD:275368
		zf-H2C2_2	584..609	CDD:290200
		C2H2 Zn finger	600..620	CDD:275368
		C2H2 Zn finger	628..648	CDD:275368
		zf-H2C2_2	640..665	CDD:290200
		C2H2 Zn finger	656..676	CDD:275368
		zf-H2C2_2	668..693	CDD:290200
		C2H2 Zn finger	684..704	CDD:275368
		zf-H2C2_2	697..720	CDD:290200
		C2H2 Zn finger	712..732	CDD:275368
		COG5048	723..>817	CDD:227381
		zf-H2C2_2	724..749	CDD:290200
		C2H2 Zn finger	740..760	CDD:275368
		zf-H2C2_2	752..777	CDD:290200
		C2H2 Zn finger	768..788	CDD:275368
		C2H2 Zn finger	795..813	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930