DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3032 and ZNF208

DIOPT Version :9

Sequence 1:	NP_001284974.1	Gene:	CG3032 / 31648	FlyBaseID:	FBgn0029928	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	405	Identity:	116/405 - (28%)
Similarity:	185/405 - (45%)	Gaps:	63/405 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 CLECRSAV---QNFEKFRR--------KADECRKQL--LEMLKKDPREPTFEVVYDGRE------ 113
            |.||..|.   .|..:.:|        |.:||.|..  ..:|.|.....|.|..|...|
Human   499 CEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKVIHTGEKPYKCEECGKAYK 563

  Fly   114 -----EDQESLHGLEPPEPAPD-PDPIDEPAIKSDKSPRKSFRGSRNTLKCSVCRRSFAHQITLA 172
                 ...:.:|.:|.|....: ....::.||   ....|.........||..|.::|:...||.
Human   564 WSSTLSYHKKIHTVEKPYKCEECGKAFNQSAI---LIKHKRIHTGEKPYKCEECGKTFSKVSTLT 625

  Fly   173 AHIRKVHEGSKRPFQCDQCEKAYSFMGGLYTHIREVHAPKERRHPCDQPGCERIYTSRIAMQKHK 237
            .| :.:|.|.| |::|.:|.|.:..:..|.|| :.:|| .|:.:.|.:  |.:.::....:.|||
Human   626 TH-KAIHAGEK-PYKCKECGKTFIKVSTLTTH-KAIHA-GEKPYKCKE--CGKAFSKFSILTKHK 684

  Fly   238 RLKHSPRDRDALKKFICEQCGASFNQSANLKYHLKTKHPTEDEVAAREGG--------------- 287
            .: |:..     |.:.||:||.:||.|:||..| |..|..|......|.|
Human   685 VI-HTGE-----KPYKCEECGKAFNWSSNLMEH-KRIHTGEKPYKCEECGKSFSTFSVLTKHKVI 742

  Fly   288 -AGERHF-CDICQKEFHSRYTLKYHTLQQHEVQEELPHECQVCGRRMAKKFMLLQHMLMHSNDK- 349
             .||:.: |:.|.|.:....||.||. :.|.|  |.|::|:.||:...:..:|::|..:|:::|
Human   743 HTGEKPYKCEECGKAYKWSSTLSYHK-KIHTV--EKPYKCEECGKAFNRSAILIKHKRIHTDEKP 804

  Fly   350 LPCEHCGRRFARRFELEAHVRAVHLKLKPFPCHHCPESFASRKTLRHHEYIHTGEKPYICDTCGQ 414
            ..||.||:.|::...|..| :|:|...||:.|..|.::|:....|..|:.||||||||.|:.||:
Human   805 YKCEECGKTFSKVSTLTTH-KAIHAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECGK 868

  Fly   415 AFRQQTCLKNHRKVH 429
            |::..:.|..|:|:|
Human   869 AYKWPSTLSYHKKIH 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3032	NP_001284974.1	zf-AD	13..95	CDD:285071	10/39 (26%)
		C2H2 Zn finger	158..179	CDD:275368	6/20 (30%)
		C2H2 Zn finger	188..209	CDD:275368	6/20 (30%)
		C2H2 Zn finger	218..239	CDD:275368	5/20 (25%)
		C2H2 Zn finger	254..275	CDD:275368	11/20 (55%)
		C2H2 Zn finger	294..315	CDD:275368	7/20 (35%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381	25/122 (20%)
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	384..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		zf-H2C2_2	511..536	CDD:290200	6/24 (25%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..575	CDD:275368	1/19 (5%)
		zf-H2C2_2	568..592	CDD:290200	3/23 (13%)
		C2H2 Zn finger	583..603	CDD:275368	3/22 (14%)
		zf-H2C2_2	596..619	CDD:290200	4/22 (18%)
		C2H2 Zn finger	611..631	CDD:275368	6/20 (30%)
		C2H2 Zn finger	639..659	CDD:275368	6/20 (30%)
		C2H2 Zn finger	667..687	CDD:275368	5/22 (23%)
		COG5048	691..1133	CDD:227381	68/198 (34%)
		C2H2 Zn finger	695..715	CDD:275368	11/20 (55%)
		zf-H2C2_2	707..732	CDD:290200	8/25 (32%)
		C2H2 Zn finger	723..743	CDD:275368	2/19 (11%)
		C2H2 Zn finger	751..771	CDD:275368	7/20 (35%)
		zf-H2C2_2	764..788	CDD:290200	10/26 (38%)
		C2H2 Zn finger	779..799	CDD:275368	5/19 (26%)
		C2H2 Zn finger	807..827	CDD:275368	8/20 (40%)
		C2H2 Zn finger	835..855	CDD:275368	5/19 (26%)
		C2H2 Zn finger	863..883	CDD:275368	7/19 (37%)
		zf-H2C2_2	876..899	CDD:290200	4/8 (50%)
		C2H2 Zn finger	891..911	CDD:275368
		C2H2 Zn finger	919..939	CDD:275368
		C2H2 Zn finger	947..967	CDD:275368
		C2H2 Zn finger	976..995	CDD:275368
		C2H2 Zn finger	1003..1023	CDD:275368
		zf-H2C2_2	1015..1039	CDD:290200
		C2H2 Zn finger	1031..1051	CDD:275368
		C2H2 Zn finger	1059..1079	CDD:275368
		C2H2 Zn finger	1087..1107	CDD:275368
		zf-H2C2_2	1099..1124	CDD:290200
		C2H2 Zn finger	1115..1135	CDD:275368
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		zf-H2C2_2	1212..1236	CDD:290200
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142373
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840