DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cm and ZIP4

DIOPT Version :9

Sequence 1:	NP_001259302.1	Gene:	cm / 31647	FlyBaseID:	FBgn0000330	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_176052.3	Gene:	ZIP4 / 842113	AraportID:	AT1G56590	Length:	415	Species:	Arabidopsis thaliana

Alignment Length:	421	Identity:	176/421 - (41%)
Similarity:	269/421 - (63%)	Gaps:	12/421 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHSLFIVNSGGEVFLEKHWRS-VVSRSVCEYFLD--AQRAAPYDVPPVIATPHYYLITVQRDTV 62
            |:..:|:::..|||.|||.... .|.||:|.:|.|  ..:...:...||||:|.:||..:.||.:
plant     1 MLQCIFLISDSGEVMLEKQLTGHRVDRSICAWFWDQYISQGDSFKALPVIASPTHYLFQIVRDGI 65

  Fly    63 SLVAACKQEVPPLFVIEFLHRVVDTFQDYFGDCSESVIKDNYVVVYELLDEMLDNGFPLATESNI 127
            :.:|..:.|:|||..||||.||.|...:|.|..:|.:||||:::||||||||:||||||.||.:|
plant    66 TFLACSQVEMPPLMAIEFLCRVADVLSEYLGGLNEDLIKDNFIIVYELLDEMIDNGFPLTTEPSI 130

  Fly   128 LKELIKPPNILRTIANTVTGK-SNVSTTLPSGQLSAVRWRRSGVRYTNNEAYFDVIEEVDAIIDK 191
            |||:|.|||::..:.:.|||. ||||.|||||..|.|.||.:..:|::||.|.|::||:|||:::
plant   131 LKEMIAPPNLVSKMLSVVTGNASNVSDTLPSGAGSCVPWRPTDPKYSSNEVYVDLVEEMDAIVNR 195

  Fly   192 SGSTVFAEIQGHIDCCIKLSGMPDLTLSFMNPRLFDDVSFHPCVRYKRWEAERLLSFIPPDGNFR 256
            .|..|..||.|.:....:|:|.|||||||.||.:.:|:.|||||||:.||:.::|||:||||.|:
plant   196 DGELVKCEIYGEVQMNSQLTGFPDLTLSFANPSILEDMRFHPCVRYRPWESHQVLSFVPPDGEFK 260

  Fly   257 LMSYHISSQSVVAIPIYIRHNFSIKTGEQG--RLDLTIGPRNTLGRTVDKVKLELTMPRCVLNCL 319
            ||||.:  :.:...|:|::...   |.:.|  |:.:.:|.|:..|:|::.:.|...:|.||.:..
plant   261 LMSYRV--KKLKNTPVYVKPQI---TSDSGTCRISVLVGIRSDPGKTIESITLSFQLPHCVSSAD 320

  Fly   320 LTPNQGKYTFDSVTKTLSWDVGRIDVSKLPNIRGSVSITPGTTNIDANPSVNVQFQISQLAVSGL 384
            |:.|.|..|..| .||.:|.:|||...|.|.:.|::::.||...:...|:..:.|:|..:|:|||
plant   321 LSSNHGTVTILS-NKTCTWTIGRIPKDKTPCLSGTLALEPGLERLHVFPTFKLGFKIMGIALSGL 384

  Fly   385 KVNRLDMYGEKYKPFKGVKYLTKAGKFQVRM 415
            ::.:||:.....:.:||.:..|:||:|.||:
plant   385 RIEKLDLQTIPPRLYKGFRAQTRAGEFDVRL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cm	NP_001259302.1	AP_MHD_Cterm	163..414	CDD:299401	95/252 (38%)
ZIP4	NP_176052.3	AP3_Mu_N	3..142	CDD:341441	65/138 (47%)
ZIP4	NP_176052.3	AP-3_Mu3_Cterm	167..414	CDD:271160	95/252 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	200	1.000	Domainoid score	I874
eggNOG	1	0.900	-	-		E1_KOG2740
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4950
Inparanoid	1	1.050	351	1.000	Inparanoid score	I611
OMA	1	1.010	-	-		QHG53686
OrthoDB	1	1.010	-	-		D928391at2759
OrthoFinder	1	1.000	-	-		FOG0003640
OrthoInspector	1	1.000	-	-		oto2905
orthoMCL	1	0.900	-	-		OOG6_102811
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2508
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840