DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cm and Ap3m1

DIOPT Version :9

Sequence 1:	NP_001259302.1	Gene:	cm / 31647	FlyBaseID:	FBgn0000330	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_061299.3	Gene:	Ap3m1 / 55946	MGIID:	1929212	Length:	418	Species:	Mus musculus

Alignment Length:	417	Identity:	287/417 - (68%)
Similarity:	354/417 - (84%)	Gaps:	3/417 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHSLFIVNSGGEVFLEKHWRSVVSRSVCEYFLDAQRAAP--YDVPPVIATPHYYLITVQRDTVS 63
            ||||||::|..|::||||||:||||:|||:||.:||..|.  .:|||||:|||:|||::.||.:.
Mouse     1 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDKLF 65

  Fly    64 LVAACKQEVPPLFVIEFLHRVVDTFQDYFGDCSESVIKDNYVVVYELLDEMLDNGFPLATESNIL 128
            .|:..:.||||||||||||||.||||||||:|||:.||||.|:|||||:||||||||||||||||
Mouse    66 FVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNIL 130

  Fly   129 KELIKPPNILRTIANTVTGKSNVSTTLPSGQLSAVRWRRSGVRYTNNEAYFDVIEEVDAIIDKSG 193
            |||||||.|||::.|::||.|||..|||:||||.:.|||:||:||||||||||:||:||||||||
Mouse   131 KELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSG 195

  Fly   194 STVFAEIQGHIDCCIKLSGMPDLTLSFMNPRLFDDVSFHPCVRYKRWEAERLLSFIPPDGNFRLM 258
            |||||||||.||.||||||||||:||||||||.||||||||:|:||||:||:||||||||||||:
Mouse   196 STVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLI 260

  Fly   259 SYHISSQSVVAIPIYIRHNFSIKTGEQ-GRLDLTIGPRNTLGRTVDKVKLELTMPRCVLNCLLTP 322
            ||.:|||::||||:|::|:.|.|.... ||.|:||||:..:|:|::.:.:.:.||:.|||..|||
Mouse   261 SYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTP 325

  Fly   323 NQGKYTFDSVTKTLSWDVGRIDVSKLPNIRGSVSITPGTTNIDANPSVNVQFQISQLAVSGLKVN 387
            .||.||||.|||.|:||||:|...|||:::|.|::..|....:.||::|:||:|.|||:||||||
Mouse   326 TQGSYTFDPVTKVLAWDVGKITPQKLPSLKGLVNLQSGAPKPEENPNLNIQFKIQQLAISGLKVN 390

  Fly   388 RLDMYGEKYKPFKGVKYLTKAGKFQVR 414
            |||||||||||||||||:|||||||||
Mouse   391 RLDMYGEKYKPFKGVKYVTKAGKFQVR 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cm	NP_001259302.1	AP_MHD_Cterm	163..414	CDD:299401	171/251 (68%)
Ap3m1	NP_061299.3	AP3_Mu_N	3..141	CDD:341441	97/137 (71%)
Ap3m1	NP_061299.3	AP-3_Mu3A_Cterm	165..418	CDD:211371	173/253 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	377	1.000	Domainoid score	I858
eggNOG	1	0.900	-	-		E1_KOG2740
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	616	1.000	Inparanoid score	I892
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53686
OrthoDB	1	1.010	-	-		D431751at33208
OrthoFinder	1	1.000	-	-		FOG0003640
OrthoInspector	1	1.000	-	-		otm44239
orthoMCL	1	0.900	-	-		OOG6_102811
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5012
SonicParanoid	1	1.000	-	-		X2508
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870