DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cm and apm3

DIOPT Version :9

Sequence 1:	NP_001259302.1	Gene:	cm / 31647	FlyBaseID:	FBgn0000330	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_595509.1	Gene:	apm3 / 2541119	PomBaseID:	SPBC651.11c	Length:	425	Species:	Schizosaccharomyces pombe

Alignment Length:	423	Identity:	105/423 - (24%)
Similarity:	201/423 - (47%)	Gaps:	33/423 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IHSLFIVNSGGEVFLEKHWRSVVSRSVCEYF---LDAQRAAPYDVPPVIATPHYYLITVQRDTVS 63
            |.::::|::.|.:.|:...|...|....|:.   |...:....:.|.::...::.:.....:.|.
pombe     4 IEAIYLVDTNGALLLQLESRGRTSPITLEHIKNELFRYKLRNEEPPFILHNKNFLIFQELEEDVR 68

  Fly    64 LVAACKQEVPPLFVIEFLHRVVDTFQDYFGDCSESVIKDNYVVVYELLDEMLDNGFPLATESNIL 128
            |......:..||::.:.:.|:||..:.:||..:.|.::.|..|:.:||.||:|.|:....|.|.|
pombe    69 LCIPTTCDTEPLYIHDIMRRIVDVVKTFFGGFNASKVEKNVCVIVQLLAEMIDYGYATCMEPNAL 133

  Fly   129 KELIKPPNILRTIANTVTGKSNVSTTLPSGQLSAVRWRRSGVRYTNNEAYFDVIEEVDAIIDKSG 193
            ::::..|:.:.... .|||   :.|..|:.....|.||.:..:|..||.:..|:|.|.|:...:|
pombe   134 QDIVPLPSFMNKFM-AVTG---LQTNTPTLARDTVPWRTAKAKYATNEFFIHVLERVSAVYQPNG 194

  Fly   194 STVFAEIQGHIDCCIKLSGMPDLTLSFMNPRLFDDVSFHPCVRYKRWEAE-RLLSFIPPDGNFRL 257
            ...|..::..::|..::||||.|.||........:|.||..|..|||:.. ..:.||||||.|.|
pombe   195 KLAFGTVKSDMECKCQISGMPLLLLSLRPGTKLGNVRFHQSVNLKRWKQHPDQIEFIPPDGKFTL 259

  Fly   258 MSYHISSQSVVAIPIYIRHNFSIKTGEQGRLDLTIGPRNTLGRTVDKVKLELTMPRCVLNCLLTP 322
            .|:.....:..::|:.:    ..|....||.::.|  |||..::|:.:|:.:|:|:.:.:  :|.
pombe   260 ASFQTDFATQKSLPVVV----EAKNKLDGRFEVRI--RNTGKKSVENLKILITIPQALKS--VTV 316

  Fly   323 NQGKYTFDSVTKT------LSWDVGRIDVSK--------LPNIRGSVSITPGTTNIDANPSVNVQ 373
            .:|.|.|.:...|      |.|.|.::..:.        |..::...:.|..:::......:::|
pombe   317 TEGNYIFRASKYTHMEEGILEWSVKKLAWTSPALVLTGFLAPLKKDANSTEESSSYSKLEHLDLQ 381

  Fly   374 FQISQLAVSGLKVNRLDM--YGEKYKPFKGVKY 404
            :::....:...||..|.|  :.:| |.:||||:
pombe   382 YKLQGSTLHNFKVESLKMLNHPDK-KSYKGVKH 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cm	NP_001259302.1	AP_MHD_Cterm	163..414	CDD:299401	69/259 (27%)
apm3	NP_595509.1	AP-3_Mu3_Cterm	164..423	CDD:271160	69/259 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2740
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53686
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5012
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.910