DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cm and Ap3m2

DIOPT Version :9

Sequence 1:	NP_001259302.1	Gene:	cm / 31647	FlyBaseID:	FBgn0000330	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_579839.1	Gene:	Ap3m2 / 140667	RGDID:	70969	Length:	418	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	290/417 - (69%)
Similarity:	357/417 - (85%)	Gaps:	3/417 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHSLFIVNSGGEVFLEKHWRSVVSRSVCEYFLDAQRAA--PYDVPPVIATPHYYLITVQRDTVS 63
            ||||||::||.|::||||||:||||||||:||.:||..|  ..:|||||.|||:||::|.|..:.
  Rat     1 MIHSLFLINSAGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVYRHKIF 65

  Fly    64 LVAACKQEVPPLFVIEFLHRVVDTFQDYFGDCSESVIKDNYVVVYELLDEMLDNGFPLATESNIL 128
            .||..:.|||||||||||||||||||||||.|||.|||||.|||||:|:||||||||||||||||
  Rat    66 FVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNGFPLATESNIL 130

  Fly   129 KELIKPPNILRTIANTVTGKSNVSTTLPSGQLSAVRWRRSGVRYTNNEAYFDVIEEVDAIIDKSG 193
            |||||||.||||:.||:||.:||...||:||||.|.|||:||:||||||||||:||:||||||||
  Rat   131 KELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAYFDVVEEIDAIIDKSG 195

  Fly   194 STVFAEIQGHIDCCIKLSGMPDLTLSFMNPRLFDDVSFHPCVRYKRWEAERLLSFIPPDGNFRLM 258
            |||.|||||.||.|:||:||||||||||||||.||||||||||:||||:||:||||||||||||:
  Rat   196 STVTAEIQGVIDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFKRWESERILSFIPPDGNFRLL 260

  Fly   259 SYHISSQSVVAIPIYIRHNFSIK-TGEQGRLDLTIGPRNTLGRTVDKVKLELTMPRCVLNCLLTP 322
            |||:|:|::||||:|::|:.|.: :|..||.::|:||:.|:|:|::.|.:...||:.|||..|||
  Rat   261 SYHVSAQNLVAIPVYVKHSISFRDSGSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLNMSLTP 325

  Fly   323 NQGKYTFDSVTKTLSWDVGRIDVSKLPNIRGSVSITPGTTNIDANPSVNVQFQISQLAVSGLKVN 387
            :||.:|||.|||.||||||:|:..|||:::|::.:..|.:..|.||::|:||:|.|||:||||||
  Rat   326 SQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMGLQVGASKPDENPTINLQFKIQQLAISGLKVN 390

  Fly   388 RLDMYGEKYKPFKGVKYLTKAGKFQVR 414
            ||||||||||||||:||:|||||||||
  Rat   391 RLDMYGEKYKPFKGIKYMTKAGKFQVR 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cm	NP_001259302.1	AP_MHD_Cterm	163..414	CDD:299401	170/251 (68%)
Ap3m2	NP_579839.1	AP3_Mu_N	3..141	CDD:341441	101/137 (74%)
Ap3m2	NP_579839.1	AP_MHD_Cterm	165..418	CDD:416027	172/253 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352711
Domainoid	1	1.000	379	1.000	Domainoid score	I813
eggNOG	1	0.900	-	-		E1_KOG2740
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4950
Inparanoid	1	1.050	619	1.000	Inparanoid score	I848
OMA	1	1.010	-	-		QHG53686
OrthoDB	1	1.010	-	-		D431751at33208
OrthoFinder	1	1.000	-	-		FOG0003640
OrthoInspector	1	1.000	-	-		otm46337
orthoMCL	1	0.900	-	-		OOG6_102811
Panther	1	1.100	-	-	O	PTHR10529
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2508
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770