DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4586 and Acox2

DIOPT Version :9

Sequence 1:	NP_572371.1	Gene:	CG4586 / 31641	FlyBaseID:	FBgn0029924	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001155139.1	Gene:	Acox2 / 93732	MGIID:	1934852	Length:	681	Species:	Mus musculus

Alignment Length:	705	Identity:	257/705 - (36%)
Similarity:	372/705 - (52%)	Gaps:	80/705 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VNADLQRERAAATLDSEDFARWWAGGSGQLEERRALERRFYEDPDFAEPVHPSCLSYKERYEQTV 67
            |:.|:..||.:.:...|.......||....|.||.:|.....||.| ...|...::..|.||..|
Mouse    18 VHPDIDSERHSPSFSVERLTNILDGGIPNTELRRRVESLIQRDPVF-NLKHLYFMTRDELYEDAV 81

  Fly    68 ARSTRFLAKLRQWQ---REKQPQLQLSVNMLRDFRLLLSGSLGTGLFQQSFPLRVHFSMFMTTLL 129
            .:  ||..:...|.   .|..|:...:..:|..:.                .|.:| .:.|..:.
Mouse    82 QK--RFHLEKLAWSLGWSEDGPERIYADRVLAGYN----------------NLNLH-GIAMNAIR 127

  Fly   130 SQGTEEQQAQW--LNRSWHMDGVLGTYAQTELGHGTFVRGLETRADYDPITQEFILNTPTQSSYK 192
            |.|::||.|:|  |.:::.   ::.|||||||||||:::||||.|.||..||||::::||.:|.|
Mouse   128 SLGSDEQIAKWGQLGKNFQ---IITTYAQTELGHGTYLQGLETEATYDATTQEFVIHSPTMTSIK 189

  Fly   193 WWPGGLGNTANVAIVLAQLYVKGKHYGLQSFVVRIRDERTHEPLTGVDVGDIGPRLGGNGVNNGF 257
            ||||.||.|...|:|||.|...|..:|:.:|:|.||....|.||.|:.||||||::|...::|||
Mouse   190 WWPGDLGRTVTHAVVLAHLICLGARHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGFENIDNGF 254

  Fly   258 LGLRDVRIPRNQMLMKNAQVLTDGTFVQGRPPLLLYGTMVYVRV-ITVKDVLFGLLQAATIATRY 321
            |.|..||:||..||.:.|:||.|||:.:...|...|..|:..|| :..|..|..|.:|.|||.||
Mouse   255 LRLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLYKGFLPTLQKACTIAVRY 319

  Fly   322 SVVRRQSRINSDQPEVSVLDHITQQAKILPQIARGVSYRL--VSDWLWRF----YEDVLRQLEDE 380
            :|:|.|||:....||..:|::.|||.|:|||:|  |||.|  ::..|.:|    |.|:|::  |.
Mouse   320 AVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLA--VSYALHFMTTSLLQFFHSSYSDILKR--DF 380

  Fly   381 STKGRNSLPELHALSCCLKAVATDEASEGVDLLRKSCGGHGFLSSANFDSIYGLTAATYTYEGEY 445
            |.     ||||||||..:||:::|..::|.::.|::|||||:...:...::.....|:.|||||.
Mouse   381 SL-----LPELHALSTGMKAMSSDFCAQGTEICRRACGGHGYSKLSGLPTLVTQAIASCTYEGEN 440

  Fly   446 TVLLLQTARFLVRQYAD------SLKRKVLPSSVSYLRDTARLIWGKNLVANC-------VRALE 497
            |||.||.||||::.|..      |:.:|.||.||.||. |.|       .|.|       .|..|
Mouse   441 TVLYLQVARFLMKSYLQAQVSPGSIPQKPLPQSVMYLA-TPR-------PARCPAQTAADFRCPE 497

  Fly   498 I-------SAMEQVRDAWQ-TQKMHQSGKVSPEMASNLAGRQLTSAAIAHAHAFFTRNALEQVEA 554
            :       .:...:|||.| ||.:.:|| |....|.|........||.||.:....||..|.||.
Mouse   498 VYTTAWAYVSARLIRDATQHTQTLMRSG-VDQYDAWNQTSVIHLQAAKAHCYFLTVRNFKEAVEK 561

  Fly   555 LRKKGDLSPNVSLILGQLVELFVIDTFLRQSGCVLRWNNGITGTQLRFVERRFEELLAKLRPNAV 619
            |    |..|.:..:|..|.:|:.::..|..||..|. :..::|.|:......|.:||..:|.:|:
Mouse   562 L----DNEPEIQRVLQNLCDLYALNGILTNSGDFLH-DGFLSGAQVDMARTAFLDLLPLIRKDAI 621

  Fly   620 ALVDGFDFHDRVLGSTLGCHDGRVYERLMEEARRNPINQEPVNSSFHNHLLPMMR 674
            .|.|.|||.|..|.|.|||:||.||:||.|.|:::|.|.:. |.::..::.|:|:
Mouse   622 LLTDAFDFSDHCLNSALGCYDGHVYQRLFEWAQKSPANTQE-NPAYKKYIRPLMQ 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:299127	251/679 (37%)
CG4586	NP_572371.1	PLN02443	7..677	CDD:178062	255/701 (36%)
Acox2	NP_001155139.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		4/9 (44%)
		AXO	20..655	CDD:173839	251/680 (37%)
		Microbody targeting signal. /evidence=ECO:0000255	679..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845540
Domainoid	1	1.000	151	1.000	Domainoid score	I4331
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	O	PTHR10909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760