Protein Alignment CG4586 and ACOX3

DIOPT Version :10

• Sequence 1: NP_572371.1
• Gene: CG4586 / 31641
• FlyBaseID: FBgn0029924
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_003492.2
• Gene: ACOX3 / 8310
• HGNCID: 121
• Length: 700
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 192/682 - (28%)
• Similarity: 329/682 - (48%)
• Gaps: 63/682 - (9%)

  Fly     7 LQRERAAATLDSEDFARWWAGGSGQLEERRALERRFYEDPDFAEPVHPSCLSYKERYEQTVARST 71
            |...||.|:...::.| .:..|.|.|..::.:......||.||.  .|......|:|     |..
Human    21 LDAYRARASFSWKELA-LFTEGEGMLRFKKTIFSALENDPLFAR--SPGADLSLEKY-----REL 77

  Fly    72 RFLAKLRQWQREKQPQLQLSVNMLRDFRLLLSGSLG-TGLFQQSFPLR--VHFSMFMTTLLSQGT 133
            .||...|.::.:     .|||..:....|.:...:. .|::..|...:  :|..:|.:.:.|.|:
Human    78 NFLRCKRIFEYD-----FLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGS 137

  Fly   134 EEQQAQWLNRSWHMDGVLGTYAQTELGHGTFVRGLETRADYDPITQEFILNTPTQSSYKWWPGGL 198
             |:...::.:.:.|: :.|.:|.|||.||:..:.:.|.|.|||.|:|||:::|...:.|:|.|.:
Human   138 -ERHLTYIQKIFRME-IFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNM 200

  Fly   199 GNTANVAIVLAQLYVKGKH-YGLQSFVVRIRDERTHEPLTGVDVGDIGPRLGGNGVNNGFLGLRD 262
            |.||..|:|.|:|.|.|.. :||..|:|:|||.:|..|:.||.|||||.:||.||::|||.....
Human   201 GKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHK 265

  Fly   263 VRIPRNQMLMKNAQVLTDGTFVQGRPPL--------LLYGTMVYVRVITVKDVLFGLLQAATIAT 319
            ||:||..:|.:...|..:||:|.   |.        ...|::...||..|...:..|..|..||.
Human   266 VRVPRQSLLNRMGDVTPEGTYVS---PFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIAL 327

  Fly   320 RYSVVRRQSRINSDQPEVSVLDHITQQAKILPQIARGVSYRLVSDWLWRFYEDVLRQLE--DEST 382
            |:|..|||.. .:::.|:.||::..||.::||.:|...:....|..|:....::.|.|.  |.|.
Human   328 RFSATRRQFG-PTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSA 391

  Fly   383 KGRNSLPELHALSCCLKAVATDEASEGVDLLRKSCGGHGFLSSANFDSIYGLTAATYTYEGEYTV 447
            :......|:|||:...|.:|:....:|:...|::|||||:|:......:........||||:..:
Human   392 RQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNI 456

  Fly   448 LLLQTARFLV----RQYADSLKRKVLPSSVSYLRDTARLIWGK---NLVANCV-RALEISAME-- 502
            ||.||:.:|:    .|..|....:....||.:|.....::..|   :.||:|: .|:.::|.:
Human   457 LLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWL 521

  Fly   503 ---QVRDAWQTQKMHQSGKVSPEMASNLAGRQLTSAAIAH----AHAFFTRNALEQVEALRKKGD 560
               .:|:.:  ||::|..:..   :|:...|  ....::|    |.||.....:::......:..
Human   522 VCYLLRETY--QKLNQEKRSG---SSDFEAR--NKCQVSHGRPLALAFVELTVVQRFHEHVHQPS 579

  Fly   561 LSPNVSLILGQLVELFVIDTFLRQSGCVLRWNNGITGTQL-RFVERRFEELLAKLRPNAVALVDG 624
            :.|::..:||:|..|:.:.:..|.:..:.| ....:|.|. ..:|.....|.::|:.:||||||.
Human   580 VPPSLRAVLGRLSALYALWSLSRHAALLYR-GGYFSGEQAGEVLESAVLALCSQLKDDAVALVDV 643

  Fly   625 FDFHDRVLGSTLGCHDGRVYERL----MEEAR 652
            ....|.||.|.:|..||.:|:.|    ::|::
Human   644 IAPPDFVLDSPIGRADGELYKNLWGAVLQESK 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:447864	192/682 (28%)
ACOX3	NP_003492.2	AXO	19..672	CDD:173839	191/677 (28%)
		Microbody targeting signal. /evidence=ECO:0000250|UniProtKB:Q63448	698..700