Protein Alignment CG4586 and ACOX2

DIOPT Version :10

• Sequence 1: NP_572371.1
• Gene: CG4586 / 31641
• FlyBaseID: FBgn0029924
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_047304998.1
• Gene: ACOX2 / 8309
• HGNCID: 120
• Length: 747
• Species: Homo sapiens
• Alignment Length: 717
• Identity: 248/717 - (34%)
• Similarity: 368/717 - (51%)
• Gaps: 95/717 - (13%)

  Fly     3 VNADLQRERAAATLDSEDFARWWAGGSGQLEERRALERRFYEDPDFAEPVHPSC-----LSYKER 62
            ::.|::.||...:.|.|.......||:.....||.:|...:..|:|      ||     ::..||
Human    84 MHPDIESERYMQSFDVERLTNILDGGAQNTALRRKVESIIHSYPEF------SCKDNYFMTQNER 142

  Fly    63 YEQTVARS--TRFLAKLRQWQREKQPQLQLSVNMLRDFRLL------LSGSLGTGLFQQSFPLRV 119
            |:..:.|:  .|.:|:...|              |.|.|.|      |||.:.         |.:
Human   143 YKAAMRRAFHIRLIARRLGW--------------LEDGRELGYAYRALSGDVA---------LNI 184

  Fly   120 HFSMFMTTLLSQGTEEQQAQWLNRSWHMDGVLGTYAQTELGHGTFVRGLETRADYDPITQEFILN 184
            | .:|:..|.|.|:|||.|:|.....::. ::.|||||||||||:::||||.|.||..||||:::
Human   185 H-RVFVRALRSLGSEEQIAKWDPLCKNIQ-IIATYAQTELGHGTYLQGLETEATYDAATQEFVIH 247

  Fly   185 TPTQSSYKWWPGGLGNTANVAIVLAQLYVKGKHYGLQSFVVRIRDERTHEPLTGVDVGDIGPRLG 249
            :||.::.|||||.||.:|..|:|.|||...|...|:.:|:|.||..:.|.||.|:.:|||||::.
Human   248 SPTLTATKWWPGDLGRSATHALVQAQLICSGARRGMHAFIVPIRSLQDHTPLPGIIIGDIGPKMD 312

  Fly   250 GNGVNNGFLGLRDVRIPRNQMLMKNAQVLTDGTFVQGRPPLLLYGTMVYVRVITVKDVLFGLLQ- 313
            .:..:||||.|..||:||..||.:.||||.|||:|:.......|..||.|||..:...:..:||
Human   313 FDQTDNGFLQLNHVRVPRENMLSRFAQVLPDGTYVKLGTAQSNYLPMVVVRVELLSGEILPILQK 377

  Fly   314 AATIATRYSVVRRQSRINSDQPEVSVLDHITQQAKILPQIARGVSYRLVSDWLWRFYEDVLRQLE 378
            |..||.||||:|||||:....||..|||:.|||.|:.||:|...::..::..|..|::.....:.
Human   378 ACVIAMRYSVIRRQSRLRPSDPEAKVLDYQTQQQKLFPQLAISYAFHFLAVSLLEFFQHSYTAIL 442

  Fly   379 DESTKGRNSLPELHALSCCLKAVATDEASEGVDLLRKSCGGHGFLSSANFDSIYGLTAATYTYEG 443
            ::..   :.||||||||..:||:.::..::|.::.|::|||||:...:...|:....:|:.||||
Human   443 NQDF---SFLPELHALSTGMKAMMSEFCTQGAEMCRRACGGHGYSKLSGLPSLVTKLSASCTYEG 504

  Fly   444 EYTVLLLQTARFLVRQYAD------SLKRKVLPSSVSYLR--DTARLIWGKNLVANCVRALEISA 500
            |.|||.||.|||||:.|..      |..::.|..||:||.  |.||        ....||.:...
Human   505 ENTVLYLQVARFLVKSYLQTQMSPGSTPQRSLSPSVAYLTAPDLAR--------CPAQRAADFLC 561

  Fly   501 MEQVRDAW-------------QTQKMHQSGKVSPEMASNLAGRQLT----SAAIAHAHAFFTRNA 548
            .|....||             ..|.:.|||....|     |..|.|    .||..|.:....:..
Human   562 PELYTTAWAHVAVRLIKDSVQHLQTLTQSGADQHE-----AWNQTTVIHLQAAKVHCYYVTVKGF 621

  Fly   549 LEQVEALRKKGDLSPNVSLILGQLVELFVIDTFLRQSGCVLRWNNGITGTQLRFVERRFEELLAK 613
            .|.:|.|..:    |.:..:|.:|.:|..|...|..||..|. :..::|.|:......:.:||..
Human   622 TEALEKLENE----PAIQQVLKRLCDLHAIHGILTNSGDFLH-DAFLSGAQVDMARTAYLDLLRL 681

  Fly   614 LRPNAVALVDGFDFHDRVLGSTLGCHDGRVYERLMEEARRNPINQEPVNSSFHNHLLPMM---RG 675
            :|.:|:.|.|.|||.|:.|.|.|||:||.|||||.:.|:::|.|.:. |.::..::.|::   |.
Human   682 IRKDAILLTDAFDFTDQCLNSALGCYDGNVYERLFQWAQKSPTNTQE-NPAYEEYIRPLLQSWRS 745

  Fly   676 KL 677
            ||
Human   746 KL 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:447864	241/685 (35%)
ACOX2	XP_047304998.1	ACAD	86..721	CDD:447864	241/686 (35%)