Protein Alignment CG4586 and ACOX1

DIOPT Version :10

• Sequence 1: NP_572371.1
• Gene: CG4586 / 31641
• FlyBaseID: FBgn0029924
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_004026.2
• Gene: ACOX1 / 51
• HGNCID: 119
• Length: 660
• Species: Homo sapiens
• Alignment Length: 692
• Identity: 266/692 - (38%)
• Similarity: 384/692 - (55%)
• Gaps: 49/692 - (7%)

  Fly     3 VNADLQRERAAATLDSEDFARWWAGGSGQLEERRALERRFYEDPDFAEPVHP--SCLSYKERYEQ 65
            :|.||:|||.:|:.:.|.......|...:...||.:|.....||||.   |.  :.|:..:|||.
Human     1 MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPDFQ---HEDLNFLTRSQRYEV 62

  Fly    66 TVARSTRFLAKLRQWQREKQPQLQLSVNMLRDFRLLLSGSLGTGLFQQSFPLRVHFSMFMTTLLS 130
            .|.:|...:.|:|::......::....|.:...|              ..||.:|..||:.|||.
Human    63 AVRKSAIMVKKMREFGIADPDEIMWFKNFVHRGR--------------PEPLDLHLGMFLPTLLH 113

  Fly   131 QGTEEQQAQWLNRSWHMDGVLGTYAQTELGHGTFVRGLETRADYDPITQEFILNTPTQSSYKWWP 195
            |.|.|||.::...:|::: ::|||||||:||||.:|||||.|.|||.|||||||:||.:|.||||
Human   114 QATAEQQERFFMPAWNLE-IIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWWP 177

  Fly   196 GGLGNTANVAIVLAQLYVKGKHYGLQSFVVRIRDERTHEPLTGVDVGDIGPRLGGNGVNNGFLGL 260
            ||||.|:|.|||||||..|||.|||.:|:|.||:..||:||.|:.||||||:.|.:.::||:|.:
Human   178 GGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYLKM 242

  Fly   261 RDVRIPRNQMLMKNAQVLTDGTFVQGRPPLLLYGTMVYVRVITVKDVLFGLLQAATIATRYSVVR 325
            .:.||||..||||.|||..|||:|:.....|.|||||:||...|.:....|.:|.|||.|||.||
Human   243 DNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVR 307

  Fly   326 RQSRINSDQPEVSVLDHITQQAKILPQIARGVSYRLVSDWLWRFYEDVLRQLEDESTKGRNSLPE 390
            .||.|...:||..:||..|||.|:.|.:|...:::.|..::...|.   |..|.......:.|||
Human   308 HQSEIKPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYH---RINEGIGQGDLSELPE 369

  Fly   391 LHALSCCLKAVATDEASEGVDLLRKSCGGHGFLSSANFDSIYGLTAATYTYEGEYTVLLLQTARF 455
            ||||:..|||..:..|:.|::..|.:|||||:...:...:||.....:.|:|||.||::||||||
Human   370 LHALTAGLKAFTSWTANTGIEACRMACGGHGYSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARF 434

  Fly   456 LVRQYADSLKRKVLPSSVSYLRDTARLIWGKNLVANCVRALEISAMEQVRDAW------------ 508
            |::.|......|::...||||.|..........||.....::|::.|.:.:|:
Human   435 LMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAARLVEIAA 499

  Fly   509 ---QTQKMHQSGKVSPEMASNLAGRQLTSAAIAHAHAFFTRNALEQVEALRKKGDLSPNVSLILG 570
               |.:.:|:..|   |:|.||....|..|:.||.|....:...|::..::.|.     :..:|.
Human   500 KNLQKEVIHRKSK---EVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKA-----IQAVLR 556

  Fly   571 QLVELFVIDTFLRQSGCVLRWNNGITGTQLRFVERRFEELLAKLRPNAVALVDGFDFHDRVLGST 635
            .|..|:.:....:.:|..|: .:.:|..|:..|.:|.:|||..:|.:||||||.|||.|..|||.
Human   557 SLCLLYSLYGISQNAGDFLQ-GSIMTEPQITQVNQRVKELLTLIRSDAVALVDAFDFQDVTLGSV 620

  Fly   636 LGCHDGRVYERLMEEARRNPINQEPVNSSFHNHLLPMMRGKL 677
            ||.:||.|||.|.|.|:.:|:|:..|:.|:.:  |..::.||
Human   621 LGRYDGNVYENLFEWAKNSPLNKAEVHESYKH--LKSLQSKL 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:447864	258/663 (39%)
ACOX1	NP_004026.2	AXO	3..637	CDD:173839	257/663 (39%)