DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4586 and acox3

DIOPT Version :9

Sequence 1:	NP_572371.1	Gene:	CG4586 / 31641	FlyBaseID:	FBgn0029924	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_998312.1	Gene:	acox3 / 406421	ZFINID:	ZDB-GENE-040426-2163	Length:	692	Species:	Danio rerio

Alignment Length:	688	Identity:	199/688 - (28%)
Similarity:	317/688 - (46%)	Gaps:	83/688 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NADLQRERAAATLDSEDFARWWAGGSGQLEERRALERRFY----EDPDFAE------PVHPSCLS 58
            |..|...|..|:...:|..|:..|     :|..|.::..:    .||.||.      ||
Zfish    10 NGPLDIYRKKASFSWKDMMRFLEG-----DELIAFKQHVFRTLESDPLFARQPGEDVPV------ 63

  Fly    59 YKERYEQTVARSTRFLAKLRQWQREKQPQLQLSVNMLRDFRLLLSGSLGTGLFQQSFPLRVHFSM 123
             :::.|.|..|..: |.|.....||:..|....:.:|.|...:...||....|       ::..|
Zfish    64 -EQKRELTFLRCKQ-LFKYDFITREELMQNPWKMTVLNDCLGMYDWSLCAKYF-------LNKGM 119

  Fly   124 FMTTLLSQGTEEQQAQWLNRSWHMDGV--------LGTYAQTELGHGTFVRGLETRADYDPITQE 180
            |..|:::.|::.          |:..|        .|.::.|||.||:..|.|.|.|.|||.|||
Zfish   120 FGATVVNTGSQR----------HLKFVKDIERMMTFGCFSLTELSHGSNTRALRTTAKYDPNTQE 174

  Fly   181 FILNTPTQSSYKWWPGGLGNTANVAIVLAQLYV-KGKHYGLQSFVVRIRDERTHEPLTGVDVGDI 244
            |::|:|...:.|:|.|.||.||..::|.||||. .||.:||.||:|::||.:|...:.||.|||:
Zfish   175 FVINSPDFEAAKFWVGNLGKTATHSVVFAQLYTPDGKCHGLHSFIVQVRDPKTLLAMPGVMVGDM 239

  Fly   245 GPRLGGNGVNNGFLGLRDVRIPRNQMLMKNAQVLTDGTFVQG-RPPLLLYGTMVYV----RVITV 304
            |.:||.||::|||....:|||||..:|.|...|..||.:|.. :.|...:|..:..    ||...
Zfish   240 GKKLGQNGLDNGFAVFHNVRIPRENLLNKTGDVAPDGQYVSPFKDPNKRFGASLGALSGGRVGIT 304

  Fly   305 KDVLFGLLQAATIATRYSVVRRQSRINSDQPEVSVLDHITQQAKILPQIARGVSYRL---VSDWL 366
            :..|..|..|.|:|.|:|..|||.....|: |:.||::..||.:::|.:|  ..|.|   ...:.
Zfish   305 RMALVNLKLAVTVAVRFSATRRQFGPKEDE-EIPVLEYQLQQWRLIPFLA--AVYALEHFTKSFS 366

  Fly   367 WRFYEDVLRQL-EDESTKGRNSLPELHALSCCLKAVATDEASEGVDLLRKSCGGHGFLSSANFDS 430
            ..|.|..:..| :|:|.:......|:|||||..|.:.:..|..|:...|::|||||:|:......
Zfish   367 MNFVEFQMGLLMKDKSDRQAELGREIHALSCASKPLGSWTAQRGIQECREACGGHGYLAMNRLGD 431

  Fly   431 IYGLTAATYTYEGEYTVLLLQTARFLVR--QYADSLKRKVLP--SSVSYLRDTARLIWGKNLVAN 491
            :........||||:..|||.||:.:|:.  |:....|.::..  .:|::|.|.:.::..|..|.:
Zfish   432 MRDDNDPNCTYEGDNNVLLQQTSNYLLSWIQHKQEGKGRIESPLETVNFLDDMSSILQSKFTVGS 496

  Fly   492 CVRALEISAMEQVRDAW-------QTQKMHQSGKVSPEMASNLAGRQLTSAAIAH-----AHAFF 544
            ....:. ||:......|       ::||     |:..|.:|.|...:..:.:..:     |.||.
Zfish   497 VEECMN-SAVPLAAYKWLVCFLLGESQK-----KLFEEKSSGLGDFEARNNSQVYYCRSLAIAFI 555

  Fly   545 TRNALEQVEALRKKGDLSPNVSLILGQLVELFVIDTFLRQSGCVLRWNNGITGTQLRFVERRFEE 609
            ....|::...|.:.......:..:||:|..|:.:.|.......:.:......|..:.|::.....
Zfish   556 EHTVLQRFHDLIQDEQTPAVLRSVLGRLCALYGLWTLTNHMAILYQGGYFSGGQPVDFIQTAILT 620

  Fly   610 LLAKLRPNAVALVDGFDFHDRVLGSTLGCHDGRVYERL 647
            |..:|:.:||||||.|...|.:|.|.:|..||.:|:.|
Zfish   621 LCGQLKDDAVALVDVFAPPDFILNSPIGKSDGELYKNL 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:299127	198/686 (29%)
CG4586	NP_572371.1	PLN02443	7..677	CDD:178062	198/685 (29%)
acox3	NP_998312.1	AXO	11..664	CDD:173839	198/687 (29%)
acox3	NP_998312.1	PLN02312	19..662	CDD:215178	196/679 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810