DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4586 and ACADVL

DIOPT Version :9

Sequence 1:	NP_572371.1	Gene:	CG4586 / 31641	FlyBaseID:	FBgn0029924	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001257376.1	Gene:	ACADVL / 37	HGNCID:	92	Length:	678	Species:	Homo sapiens

Alignment Length:	686	Identity:	145/686 - (21%)
Similarity:	232/686 - (33%)	Gaps:	189/686 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RWWAGGSGQL-------EERRALERR---FYEDPDFAEPV------------HPSCLSYKERYEQ 65
            |.:|||:.||       ....||.|:   ..|...||..:            :||.|:.::
Human    61 RPYAGGAAQLALDKSDSHPSDALTRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQ---- 121

  Fly    66 TVARSTRFLAKL-----RQWQREKQPQLQLSVNMLRD-----------FRLLLSGSL-GTGLFQQ 113
                 |:||.:|     |.::....|....::.|:.:           |.|.:...| |.||...
Human   122 -----TQFLKELVEPVSRFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNT 181

  Fly   114 SF----------------PLRVHFSMFMTTLLSQGTEEQQAQWLNRSWHMDGVLGTYAQTELGHG 162
            .:                .|..|.|:....:|..||:.|:.::|.:....:.| ..:..||...|
Human   182 QYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETV-AAFCLTEPSSG 245

  Fly   163 TFVRGLETRADYDPITQEFILNTPTQSSYKWW--PGGLGNTANVAIVLAQLYVKGKHYGLQSFVV 225
            :....:.|.|...|..:.:.||     ..|.|  .|||   |::..|.|:
Human   246 SDAASIRTSAVPSPCGKYYTLN-----GSKLWISNGGL---ADIFTVFAK--------------- 287

  Fly   226 RIRDERTHEPLTGVDVGDIGPRLGGNGVNNGFLGLRDVRIPRNQMLMK---NAQVLTDGTFVQGR 287
                    .|:|....|.:..::....|..||.|:.. ..|..:|.:|   .|:|..||..|...
Human   288 --------TPVTDPATGAVKEKITAFVVERGFGGITH-GPPEKKMGIKASNTAEVFFDGVRVPSE 343

  Fly   288 PPLLLYGTMVYVRVITVKDVLFGLLQAATIATRYSVVRRQSRINSDQPEVSVLDHITQQAKILPQ 352
            ..|...|:...|.:..:.:..|| :.||...|...::.:            .:||.|.:.:...:
Human   344 NVLGEVGSGFKVAMHILNNGRFG-MAAALAGTMRGIIAK------------AVDHATNRTQFGEK 395

  Fly   353 IARGVSYRLVSDWLWRFYEDVLRQLEDESTKGRNSLPELHALSCCLKAVATD---EA-------S 407
            |.   ::.|:.:.|.|.   |:.|...||.        .:.:|..:...|||   ||       |
Human   396 IH---NFGLIQEKLARM---VMLQYVTESM--------AYMVSANMDQGATDFQIEAAISKIFGS 446

  Fly   408 EGVDLLRKSC----GGHGFLSSANFDSIYGLTAATYTYEGEYTVLLLQTARFLVRQYADSLKRKV 468
            |....:...|    ||.||:.....:.:.........:||...:|     |..|.......|.|.
Human   447 EAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDIL-----RLFVALQGCMDKGKE 506

  Fly   469 LPSSVSYLRDTARLIWGKNLVANCVRALEISAMEQVRDAWQTQKMHQSGKVSPEM--ASNLAGRQ 531
            |....|.|         ||...|....|..:..:..|.|.....:..||.|.||:  :..||.|
Human   507 LSGLGSAL---------KNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVR- 561

  Fly   532 LTSAAIAHAHAFFTRNALEQ----VEA---LRKKGDLSPNVSLILGQL----VELFVIDTFLRQS 585
                            ||||    |||   ..|||.:  |...:|.:|    ::|:.:...|.::
Human   562 ----------------ALEQFATVVEAKLIKHKKGIV--NEQFLLQRLADGAIDLYAMVVVLSRA 608

  Fly   586 GCVLRWNNGITGTQLRFVERRFEELLAKLRPNAVAL 621
            ...|...:.....:....:....|..|::|....||
Human   609 SRSLSEGHPTAQHEKMLCDTWCIEAAARIREGMAAL 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:299127	145/686 (21%)
CG4586	NP_572371.1	PLN02443	7..677	CDD:178062	145/686 (21%)
ACADVL	NP_001257376.1	VLCAD	95..504	CDD:173850	95/482 (20%)
ACADVL	NP_001257376.1	CaiA	125..496	CDD:224871	87/435 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810