DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4586 and ACAD9

DIOPT Version :9

Sequence 1:	NP_572371.1	Gene:	CG4586 / 31641	FlyBaseID:	FBgn0029924	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_054768.2	Gene:	ACAD9 / 28976	HGNCID:	21497	Length:	621	Species:	Homo sapiens

Alignment Length:	498	Identity:	115/498 - (23%)
Similarity:	187/498 - (37%)	Gaps:	115/498 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LRVHFSMFMTTLLSQGTEEQQAQWLNR---SWHMDGVLGTYAQTELGHGTFVRGLETRADYDPIT 178
            |..|.::.:..::..|||||:|::|.:   ..|    :..:..||...|:....:.:||......
Human   142 LAAHQAIGLKGIILAGTEEQKAKYLPKLASGEH----IAAFCLTEPASGSDAASIRSRATLSEDK 202

  Fly   179 QEFILNTPTQSSYKWW--PGGLGNT----ANVAIVLAQLYVKGKHYGLQSFVVRIRDERTHEPLT 237
            :.:|||     ..|.|  .|||.|.    |...:|.:...||.|   :.:|:|. ||      ..
Human   203 KHYILN-----GSKVWITNGGLANIFTVFAKTEVVDSDGSVKDK---ITAFIVE-RD------FG 252

  Fly   238 GVDVGDIGPRLGGNGVNNGFLGLRDVRIPRNQML------------MKNAQVLTDGTFVQGRPPL 290
            ||..|....:||..|.|...:...:.:||...:|            :.|:...:.|:.|.|....
Human   253 GVTNGKPEDKLGIRGSNTCEVHFENTKIPVENILGEVGDGFKVAMNILNSGRFSMGSVVAGLLKR 317

  Fly   291 LLYGTMVYV---RVITVKDVLFGLLQA--ATIATRYSVVRRQSRINS---DQP-------EVSVL 340
            |:..|..|.   :....:...|||:|.  |.:|.:..|:...:.:.:   |||       |.:::
Human   318 LIEMTAEYACTRKQFNKRLSEFGLIQEKFALMAQKAYVMESMTYLTAGMLDQPGFPDCSIEAAMV 382

  Fly   341 DHITQQA------KILPQIARGVSYRLVSDWLWRFYEDVLRQ----LEDESTK------------ 383
            ...:.:|      :.| ||..|:.|  ..|:.   ||.:||.    |..|.|.
Human   383 KVFSSEAAWQCVSEAL-QILGGLGY--TRDYP---YERILRDTRILLIFEGTNEILRMYIALTGL 441

  Fly   384 ---GRNSLPELHAL-----SCCLKAVA---TDEASEGVDLLRKSCGGHGFLSSANFDSIYGLTAA 437
               ||.....:|.|     |..:..|.   .|.....|||  ...|.||.:..:..||.......
Human   442 QHAGRILTTRIHELKQAKVSTVMDTVGRRLRDSLGRTVDL--GLTGNHGVVHPSLADSANKFEEN 504

  Fly   438 TYTYEGEYTVLLLQTARFLVRQYADSLKR------------KVLPSSVSYLRDTARLIWGKNLVA 490
            ||.:......|||:..:.::.:.. .|||            .||..:...:|...|....:.|:|
Human   505 TYCFGRTVETLLLRFGKTIMEEQL-VLKRVANILINLYGMTAVLSRASRSIRIGLRNHDHEVLLA 568

  Fly   491 N--CVRAL--EISAMEQVRDAWQTQKM-HQSGKVSPEMASNLA 528
            |  ||.|.  .:.::.|: |.:..:.: .|..|||.::....|
Human   569 NTFCVEAYLQNLFSLSQL-DKYAPENLDEQIKKVSQQILEKRA 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:299127	115/498 (23%)
CG4586	NP_572371.1	PLN02443	7..677	CDD:178062	115/498 (23%)
ACAD9	NP_054768.2	VLCAD	38..445	CDD:173850	75/327 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810