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Protein Alignment CG4586 and GCDH

DIOPT Version :9

Sequence 1:	NP_572371.1	Gene:	CG4586 / 31641	FlyBaseID:	FBgn0029924	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_000150.1	Gene:	GCDH / 2639	HGNCID:	4189	Length:	438	Species:	Homo sapiens

Alignment Length:	499	Identity:	106/499 - (21%)
Similarity:	184/499 - (36%)	Gaps:	160/499 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RWWAGGSGQLEERRALERRFYED--PDFAEPVHPSCLSYKERYEQTVARSTRFLAKLRQWQREK- 84
            |.|...:.|.|:....:.:..:.  |:| :...|..|..:...::.:.|.|     .|.:.:|:
Human    21 RTWVSSAAQTEKGGRTQSQLAKSSRPEF-DWQDPLVLEEQLTTDEILIRDT-----FRTYCQERL 79

  Fly    85 QPQLQLSVNMLRDFRLLLS--GSLGT------------------GLFQQSF---------PLRVH 120
            .|::.|:.......|.::|  |.||.                  ||..:..         .:.|.
Human    80 MPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQ 144

  Fly   121 FSMFMTTLLSQGTEEQQAQWLNRSWHMDGVLGTYAQTELGHGTFVRGLETRADYDPITQEFILNT 185
            .|:.|..:.:.|:|||:.::|.:....: :||.:..||...|:....:||||.|:...:.:.||
Human   145 SSLVMHPIYAYGSEEQRQKYLPQLAKGE-LLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLN- 207

  Fly   186 PTQSSYKWWPGGLGNTANVAIVLAQLYVKGKHYGLQSFVVRIRDERTHEPLTGVDVGDIGPRLGG 250
                ..|.|   :.|:.     :|.|           |||..|.|
Human   208 ----GTKTW---ITNSP-----MADL-----------FVVWARCE-------------------- 229

  Fly   251 NGVNNGFL---GLRDVRIPRNQ---MLMKNA--QVLTDGTFVQ-----------GRPPLLLYGTM 296
            :|...|||   |:|.:..||.|   .|..:|  .::.||..|.           |.|    :|.:
Human   230 DGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGP----FGCL 290

  Fly   297 VYVRVITVKDVLFGLLQAATI----ATRYSVVRRQSRINSDQPEVSVLDHITQQ--AKILPQIAR 355
            ...|.    .:.:|:|.|:..    |.:|::.|.|..:...:      :.:.|:  |.:|.:|..
Human   291 NNARY----GIAWGVLGASEFCLHTARQYALDRMQFGVPLAR------NQLIQKKLADMLTEITL 345

  Fly   356 GVSYRLVSDWLWRFYEDVLRQLEDESTKGRNSLPELHAL---SCCLKAVATDEASEGVDLLRKSC 417
            |:...|           .|.:|:|:.    .:.||:.:|   :.|.||:  |.|.:..|:|
Human   346 GLHACL-----------QLGRLKDQD----KAAPEMVSLLKRNNCGKAL--DIARQARDML---- 389

  Fly   418 GGHGFLS-------SANFDSIYGLTAATYTYEGEYTVLLLQTAR 454
            ||:|...       :.|.:       |..||||.:.:..|...|
Human   390 GGNGISDEYHVIRHAMNLE-------AVNTYEGTHDIHALILGR 426

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.