DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4586 and Acadvl

DIOPT Version :9

Sequence 1:	NP_572371.1	Gene:	CG4586 / 31641	FlyBaseID:	FBgn0029924	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_037023.1	Gene:	Acadvl / 25363	RGDID:	2014	Length:	655	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	148/725 - (20%)
Similarity:	249/725 - (34%)	Gaps:	216/725 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVNADLQRERAAATLDSEDFARWWAGGSGQLEERRALERRFYEDPDFAEPVHPSCLS--YKERYE 64
            ::::|.......|..:|:.||      .|..:.:...::.|         .:||.|:  ..:..:
  Rat    54 TLSSDASTREKPARAESKSFA------VGMFKGQLTTDQVF---------PYPSVLNEGQTQFLK 103

  Fly    65 QTVARSTRFL------AKLRQWQREKQPQLQLSVNMLRDFRLLLSGSL-GTGLFQQ--------- 113
            :.|....||.      ||....::.::..|| .:..|..|.|.:...| |.||...
  Rat   104 ELVGPVARFFEEVNDPAKNDSLEKVEEDTLQ-GLKELGAFGLQVPSELGGLGLSNTQYARLAEIV 167

  Fly   114 -------SFPLRVHFSMFMTTLLSQGTEEQQAQWLNRSWHMDG-VLGTYAQTELGHGTFVRGLET 170
                   |..|..|.|:....:|..||:.|:.::|.|.  ..| .|..:..||...|:.|..:.:
  Rat   168 GMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRV--ASGQALAAFCLTEPSSGSDVASIRS 230

  Fly   171 RADYDPITQEFILNTPTQSSYKWW--PGGLGNTANVAIVLAQLYVKGKHYG-----LQSFVVRIR 228
            .|...|..:.:.||     ..|.|  .|||   |::..|.|:..:|....|     :.:|||
  Rat   231 SAVPSPCGKYYTLN-----GSKIWISNGGL---ADIFTVFAKTPIKDAATGAVKEKITAFVV--- 284

  Fly   229 DERTHEPLTGVDVGDIGPRLGGNGVNNGFLGLRDVRIPRNQMLMK---NAQVLTDGTFVQGRPPL 290
             ||:.                 .||.:|        :|..:|.:|   .::|..||..|.....|
  Rat   285 -ERSF-----------------GGVTHG--------LPEKKMGIKASNTSEVYFDGVKVPAENVL 323

  Fly   291 LLYGTMVYVRVITVKDVLFGLLQAATIA-TRYSVVRRQSRINSDQPEVSVLDHITQQAK------ 348
            ...|....|.|..:.:..||:  |||:| |..:::.:            .:||.|.:.:
  Rat   324 GEVGDGFKVAVNILNNGRFGM--AATLAGTMKAIIAK------------AVDHATNRTQFGDKIH 374

  Fly   349 ----ILPQIARGVSYRLVSDWLWRFYEDVLRQLEDESTKGRNSLPELHALSCCLKAVATDEASEG 409
                |..::||....:.|:       |.:...|.....:|........|:|   |...::.|.:.
  Rat   375 NFGVIQEKLARMAILQYVT-------ESMAYMLSANMDQGFKDFQIEAAIS---KIFGSEAAWKV 429

  Fly   410 VDLLRKSCGGHGFLSSANFDSIYGLTAATYTYEGEYTVLLLQTARFLVRQYADSLKRKVLPSSVS 474
            .|...:..||.||:.....:.:.........:||...:|     |..|.......|.|.|....:
  Rat   430 TDECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGTNDIL-----RLFVALQGCMDKGKELTGLGN 489

  Fly   475 YLRDTARLIWGKNLVANCVRALEISAMEQVRDAWQTQKMHQSGKVSPEMASNLAGRQLTSAAIAH 539
            .|         ||.:.| |..|...|.:|:|        .::|          .|..|:.:.|.|
  Rat   490 AL---------KNPLGN-VGLLIGEASKQLR--------RRTG----------IGSGLSLSGIVH 526

  Fly   540 AHAFFTRNALEQVEALRKKGDLSPNVSLILGQLVELF--VIDTFLRQSGCVLRWNNGITGTQLRF 602
            ..             |.:.|:|:.       |.:|.|  |::..|      ::...||...|.
  Rat   527 PE-------------LSRSGELAV-------QALEQFATVVEAKL------MKHKKGIVNEQF-- 563

  Fly   603 VERRFEELLAKLRPNAV--------------ALVDGFDF--HDRVLGSTLGCHDG--RVYERLME 649
                   ||.:|...|:              :|.:|:..  |:::|..: .|.:.  |:.|. |.
  Rat   564 -------LLQRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDS-WCIEAATRIREN-MA 619

  Fly   650 EARRNPINQE 659
            ..:.||..||
  Rat   620 SLQSNPQQQE 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:299127	144/713 (20%)
CG4586	NP_572371.1	PLN02443	7..677	CDD:178062	147/720 (20%)
Acadvl	NP_037023.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		2/15 (13%)
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	41..482		105/511 (21%)
		VLCAD	72..481	CDD:173850	101/492 (21%)
		CaiA	100..473	CDD:224871	93/441 (21%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	461..463		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	483..516		11/60 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810