DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4586 and Acox2

DIOPT Version :9

Sequence 1:	NP_572371.1	Gene:	CG4586 / 31641	FlyBaseID:	FBgn0029924	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_665713.2	Gene:	Acox2 / 252898	RGDID:	628684	Length:	681	Species:	Rattus norvegicus

Alignment Length:	717	Identity:	247/717 - (34%)
Similarity:	368/717 - (51%)	Gaps:	102/717 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VNADLQRERAAATLDSEDFARWWAGGSGQLEERRALERRFYEDPDF-AEPVHPSCLSYKERYEQT 66
            |:.|:..||.:.:...|.......||......||.:|.....||.| .:.::  .::.:|.||..
  Rat    18 VHPDIDSERHSPSFSVERLTNILDGGLPNTVLRRKVESIIQSDPVFNLKKLY--FMTREELYEDA 80

  Fly    67 VARSTRFLAKLRQWQ---REKQPQLQLSVNMLRDFRLLLSGSLGTGLFQQSFPLRVHFSMFMTTL 128
            :.:  ||..:...|.   .|..|: ::..|.:.|..:.||               :| .:.|..:
  Rat    81 IQK--RFHLEKLAWSLGWSEDGPE-RIYANRVLDGNVNLS---------------LH-GVAMNAI 126

  Fly   129 LSQGTEEQQAQW--LNRSWHMDGVLGTYAQTELGHGTFVRGLETRADYDPITQEFILNTPTQSSY 191
            .|.|::||.|:|  |.:::.   ::.|||||||||||:::||||.|.||...|||::::||.:|.
  Rat   127 RSLGSDEQIAKWGQLCKNFQ---IITTYAQTELGHGTYLQGLETEATYDEARQEFVIHSPTMTST 188

  Fly   192 KWWPGGLGNTANVAIVLAQLYVKGKHYGLQSFVVRIRDERTHEPLTGVDVGDIGPRLGGNGVNNG 256
            |||||.||.:...|:|||||...|..:|:.:|:|.||....|.||.|:.||||||::|...::||
  Rat   189 KWWPGDLGWSVTHAVVLAQLTCLGVRHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGLEHIDNG 253

  Fly   257 FLGLRDVRIPRNQMLMKNAQVLTDGTFVQGRPPLLLYGTMVYVRV-ITVKDVLFGLLQAATIATR 320
            ||.|..||:||..||.:.|:||.|||:.:...|...|..|:..|| :..|.:|..|.:|..||||
  Rat   254 FLQLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLCKGILPSLQKACIIATR 318

  Fly   321 YSVVRRQSRINSDQPEVSVLDHITQQAKILPQIARGVSYRL------VSDWLWRFYEDVLRQLED 379
            |||:|.|||:....||..:|::.|||.|:|||:|  |||..      :|::....|..:|::  |
  Rat   319 YSVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLA--VSYAFHFTATSLSEFFHSSYSAILKR--D 379

  Fly   380 ESTKGRNSLPELHALSCCLKAVATDEASEGVDLLRKSCGGHGFLSSANFDSIYGLTAATYTYEGE 444
            .|.     ||||||||..:||...|..::|.::.|::|||||:...:...::.....|:.|||||
  Rat   380 FSL-----LPELHALSTGMKATFADFCAQGAEICRRACGGHGYSKLSGLPTLVARATASCTYEGE 439

  Fly   445 YTVLLLQTARFLVRQYAD------SLKRKVLPSSVSYLR------------------DTARLIW- 484
            .|||.||.||||::.|..      :..:|.||.||.|:.                  |.....|
  Rat   440 NTVLYLQVARFLMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYTTAWA 504

  Fly   485 --GKNLV---ANCVRALEISAMEQVRDAW-QTQKMHQSGKVSPEMASNLAGRQLTSAAIAHAHAF 543
              ...|:   |:..:.|..|.::| .||| ||..:|                  ..||.|:.:..
  Rat   505 YVSTRLIRDAAHRTQTLMKSGVDQ-HDAWNQTTVIH------------------LQAAKAYCYFI 550

  Fly   544 FTRNALEQVEALRKKGDLSPNVSLILGQLVELFVIDTFLRQSGCVLRWNNGITGTQLRFVERRFE 608
            ..:|..|.||.|    |..|.:..:|.:|.:|:.:...|..||..|. :..::|.|:......|.
  Rat   551 TVKNFKEAVEKL----DKEPEIQRVLQRLCDLYALHGVLTNSGDFLH-DGFLSGAQVDMAREAFL 610

  Fly   609 ELLAKLRPNAVALVDGFDFHDRVLGSTLGCHDGRVYERLMEEARRNPINQEPVNSSFHNHLLPMM 673
            :||..:|.:|:.|.|.|||.|..|.|.|||:||.|||||.|.|:::|.|.:. |.::..::.|:|
  Rat   611 DLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYERLFEWAQKSPANTQE-NPAYKKYIRPLM 674

  Fly   674 RG 675
            .|
  Rat   675 LG 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:299127	240/690 (35%)
CG4586	NP_572371.1	PLN02443	7..677	CDD:178062	245/713 (34%)
Acox2	NP_665713.2	AXO	20..655	CDD:173839	240/691 (35%)
Acox2	NP_665713.2	Microbody targeting signal. /evidence=ECO:0000255	679..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348953
Domainoid	1	1.000	108	1.000	Domainoid score	I6284
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	O	PTHR10909
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.760