DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4586 and acox-1.1

DIOPT Version :9

Sequence 1:	NP_572371.1	Gene:	CG4586 / 31641	FlyBaseID:	FBgn0029924	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001021089.1	Gene:	acox-1.1 / 173162	WormBaseID:	WBGene00008564	Length:	674	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	254/696 - (36%)
Similarity:	386/696 - (55%)	Gaps:	68/696 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NADLQRERAAATLDSEDFARWWAGGSGQLEERRALERRFYEDPDFAEPVHPSC-LSYKERYEQTV 67
            |.||..||..||.|:...|....||..:...||.:..:..|.|:    :|.|. |.|..| |:.:
Worm    13 NPDLTAERLTATFDTHAMAAQIYGGEMRARRRREITAKLAEIPE----LHDSMPLPYMTR-EEKI 72

  Fly    68 ARSTRFLAKLRQWQRE-KQPQLQLSVNMLRDFRLLLSGSLGTGLFQQSFPLRVHFSMFMTTLLSQ 131
            ..|.|.|..|.|...| ..|.....:..|.:..|.:.|:          |:.:|..||:..|.:|
Worm    73 MESARKLTVLTQRMSEIIDPTDAGELYHLNNEVLGIEGN----------PMALHGVMFIPALNAQ 127

  Fly   132 GTEEQQAQWLNRSWHMDGVLGTYAQTELGHGTFVRGLETRADYDPITQEFILNTPTQSSYKWWPG 196
            .::||||:||.|:...: ::|||||||:||||.::.|||.|.||..||||:|:||..::.|||||
Worm   128 ASDEQQAKWLIRALRRE-IIGTYAQTEMGHGTNLQNLETTATYDIGTQEFVLHTPKITALKWWPG 191

  Fly   197 GLGNTANVAIVLAQLYVKGKHYGLQSFVVRIRDERTHEPLTGVDVGDIGPRLGGNGVNNGFLGLR 261
            .||.::|.|:|:|.:|:|||::|..:|:|.:|||:||:||.|:.:|||||::..|.|:|||||..
Worm   192 NLGKSSNYAVVVAHMYIKGKNFGPHTFMVPLRDEKTHKPLPGITIGDIGPKMAYNIVDNGFLGFN 256

  Fly   262 DVRIPRNQMLMKNAQVLTDGTFVQGRPP--LLLYGTMVYVRVITVKDVLFGLLQAATIATRYSVV 324
            :.||||..:||::.:|..|||::  :||  .:.|..||:||...:......|..|..||||||.|
Worm   257 NYRIPRTNLLMRHTKVEADGTYI--KPPHAKINYSAMVHVRSYMLTGQAIMLSYALNIATRYSAV 319

  Fly   325 RRQSRINSDQPEVSVLDHITQQAKILPQIARGVSYRLVSDWLWRFYEDVLRQLEDESTKGRNSL- 388
            |||.:|:.::|||.||::.|||.::.|.|||..:::.......:.||.||::::    .|..||
Worm   320 RRQGQIDKNEPEVKVLEYQTQQHRLFPFIARAYAFQFAGAETVKLYERVLKEMK----SGNVSLM 380

  Fly   389 PELHALSCCLKAVATDEASEGVDLLRKSCGGHGFLSSANFDSIYGLTAATYTYEGEYTVLLLQTA 453
            .:||||:..||:|.|.:..||::..|.:|||||:..::....|||:.....|||||..|:|||.|
Worm   381 ADLHALTSGLKSVVTHQTGEGIEQARMACGGHGYSMASYISEIYGVAIGGCTYEGENMVMLLQLA 445

  Fly   454 RFLVRQYA--DSLKRKVLPSSVSYL---RDTARLIWGKNLVAN-----CVRALE-ISAMEQVRDA 507
            |:||:..|  .|.|...|...|:||   .:...||   :.|.|     .::..: |:..:.::.|
Worm   446 RYLVKSAALVKSGKASQLGPLVAYLGARSEPTSLI---DRVPNGGITEYIKTFQHIAKRQTLKAA 507

  Fly   508 WQTQKMHQSGKVSPEMASNLAGRQLTSAAIAHAHAFFTRNALEQVEALRKK----GDLSPNVSLI 568
            .:...:.::|: ..|:|.|.:..:|..|:..|...|.       |||..::    ||::  :...
Worm   508 NKFFGLMENGE-KREIAWNKSSVELNRASRLHTRLFI-------VEAFARRVNEIGDIT--IKEA 562

  Fly   569 LGQLVELFV------IDTFLRQSGCVLRWNNGITGTQLRFVERRFEELLAKLRPNAVALVDGFDF 627
            |..|:.|.|      :.|:..:.|.       ::.|||.:|..:....|.|:|||||:|:|.::|
Worm   563 LSDLLHLHVNYELLDVATYALEDGF-------MSSTQLDYVRDQLYFYLQKIRPNAVSLLDSWEF 620

  Fly   628 HDRVLGSTLGCHDGRVYERLMEEARRNPINQEPVNSSFHNHLLPMM 673
            .||.|.|.||..||.|||.|.:.|:.:|:|:..|..|...:|.|||
Worm   621 SDRELRSVLGRRDGHVYENLFKWAKESPLNKTDVLPSVDTYLKPMM 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4586	NP_572371.1	ACAD	6..653	CDD:299127	245/672 (36%)
CG4586	NP_572371.1	PLN02443	7..677	CDD:178062	252/693 (36%)
acox-1.1	NP_001021089.1	ACAD	14..645	CDD:299127	244/672 (36%)
acox-1.1	NP_001021089.1	PLN02443	16..674	CDD:178062	252/693 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163705
Domainoid	1	1.000	206	1.000	Domainoid score	I1698
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I803
Isobase	1	0.950	-	0	Normalized mean entropy	S1686
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	1	1.000	-	-		mtm4727
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	O	PTHR10909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.860