DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Setd3 and RKM1

DIOPT Version :9

Sequence 1:	NP_727144.1	Gene:	Setd3 / 31638	FlyBaseID:	FBgn0052732	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_015116.1	Gene:	RKM1 / 855893	SGDID:	S000006129	Length:	583	Species:	Saccharomyces cerevisiae

Alignment Length:	310	Identity:	55/310 - (17%)
Similarity:	98/310 - (31%)	Gaps:	117/310 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 DELVLSVPRKLILSEENNSDCRLFGKMTQATHLN----LAY---------DLVIEKIRGEFSEWR 207
            |...:.:|.::::|  .|...:.||......::|    |.:         |.:::.:|.. .:::
Yeast    43 DNPSIKIPPEIVIS--RNLPMKFFGLSESTKNINGWLKLFFAKIKFDRDNDTIVDNVRVN-DKFK 104

  Fly   208 PYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQYAFLYKYAHTMTEPSTGNRSHP 272
            ||:|.||::.|:.|.:...:::.|..|                              :.||..|.
Yeast   105 PYLDALPSRLNSPLVWNPSELKRLSST------------------------------NIGNSIHE 139

  Fly   273 GERGLF------------------------------FTQHGLCYKLYR---------WAVSTVMT 298
            ...|:|                              .|...|..|:.:         |.......
Yeast   140 KFEGIFKEWFELVSSSDMFDLERVADDVQTFHNLDELTYEALYEKILKITELQRPTIWYSFPAFL 204

  Fly   299 RQNLVPSEKQESE-----DGPKLISALIPYWDMANHRPGKITSFY-------------ATVSRQL 345
            ..:|:...:...|     :.|.....|:|..|:.||.......:|             |:.||:|
Yeast   205 WSHLIFISRAFPEYVLNRNCPDNSIVLLPIVDLLNHDYRSKVKWYPENGWFCYEKIGTASQSREL 269

  Fly   346 ECTAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVDPNNTKDYVNIRVGLSL 395
            ...              ||.:.|.:||...|||..:|..|.|.::|.|.|
Yeast   270 SNN--------------YGGKGNEELLSGYGFVLEDNIFDSVALKVKLPL 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	47/291 (16%)
Setd3	NP_727144.1	Rubis-subs-bind	400..524	CDD:370401
RKM1	NP_015116.1	SET	10..288	CDD:394802	47/291 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001685
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101154
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	1	1.000	-	-		X3007
TreeFam	0	0.000	Not matched by this tool.
	7	6.670