DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Setd3 and RKM3

DIOPT Version :9

Sequence 1:	NP_727144.1	Gene:	Setd3 / 31638	FlyBaseID:	FBgn0052732	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_009586.1	Gene:	RKM3 / 852318	SGDID:	S000000234	Length:	552	Species:	Saccharomyces cerevisiae

Alignment Length:	396	Identity:	75/396 - (18%)
Similarity:	116/396 - (29%)	Gaps:	158/396 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 DDQTRLAKVEAFSAWAKDGGVHSEGLEIAIFPGYQLGLRATRPLAKDELVLSVPRKLILSEENNS 174
            ||..|:.|..|..    :|.......:|...|...||:.|...:|:.|.:|::.:..|.|..|:|
Yeast     7 DDVHRILKFVANC----NGRFEDSKCDIRESPLGGLGVFAKTDIAEGESILTLNKSSIFSASNSS 67

  Fly   175 ------DCRLFGKMTQATHLNLAYDLVIEKIRGEFSEWRPYIDV-----------LPAKYNTVLY 222
                  |..:.|.:.    ||:|:.......|.. |.|.|::..           ||..     :
Yeast    68 IANLLCDSSIDGMLA----LNIAFIYETTVFRNS-SHWYPFLRTIRIRDDEGHLNLPPS-----F 122

  Fly   223 FTTKQMELLRGTAAAAL--AMRQCRVIAKQYAFLYKYAHTMTEPSTGNRSHPGERGLFFTQHGLC 285
            :......||:||:...|  ::.....|.:.:......||...:          |.||
Yeast   123 WHADAKRLLKGTSFDTLFDSLAPEEEIMEGFEIAVDLAHKWND----------EFGL-------- 169

  Fly   286 YKLYRWAVSTVMTRQNLVPSEKQESEDG----PKLIS------------------ALIPYWDMAN 328
                      .:.:..|..||:...||.    .|.||                  ||:|..|:.|
Yeast   170 ----------EIPKGFLDVSEENHEEDYNLKLEKFISVAYTLSSRGFEIDAYHETALVPIADLFN 224

  Fly   329 HRPG-----------------------------------------KITSF--------------- 337
            |...                                         |:.|.
Yeast   225 HHVSDPDLKFVSLYDVCDKCGEPDMCKHLIAEEYLEAENLDKNMPKVASMETRVIDEDLIKSLEN 289

  Fly   338 -----YATVSRQL-----------EC---TAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVDPNNT 383
                 |:.|:..:           ||   ..:..|..|::.|..||:.||..||...||..|.|.
Yeast   290 DLEKEYSNVTANIEDDDGGIENPDECVDLVLKNDVAQGQEIFNSYGELSNVFLLARYGFTVPENQ 354

  Fly   384 KDYVNI 389
            .|.|::
Yeast   355 YDIVHL 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	66/374 (18%)
Setd3	NP_727144.1	Rubis-subs-bind	400..524	CDD:370401
RKM3	NP_009586.1	SET_LSMT	27..349	CDD:380925	64/359 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13271
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910