DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Setd3 and RKM4

DIOPT Version :9

Sequence 1:	NP_727144.1	Gene:	Setd3 / 31638	FlyBaseID:	FBgn0052732	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_010543.1	Gene:	RKM4 / 851844	SGDID:	S000002665	Length:	494	Species:	Saccharomyces cerevisiae

Alignment Length:	311	Identity:	67/311 - (21%)
Similarity:	127/311 - (40%)	Gaps:	63/311 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 DDQTRLAKVEAFSAWAKDGGVHSEGLEIAIFPGYQL----------GLRATRPLAKDELVLSVPR 164
            ||.:|  ..|.|..|.|...      ||.:.|..::          .:.||:.:.|||.:..:||
Yeast     2 DDFSR--DTENFVCWLKTTA------EIEVSPKIEIKDLCCDNQGRAVVATQKIKKDETLFKIPR 58

  Fly   165 KLILSEENNSDCR----LFGKMTQATH------LNLAYDLVIEKIRGEFSEWRPYIDV--LPAKY 217
            ..:||...:...:    |..|....|.      :.:.|::   ::..|.|.|.||..|  .|:..
Yeast    59 SSVLSVTTSQLIKDYPSLKDKFLNETGSWEGLIICILYEM---EVLQERSRWAPYFKVWNKPSDM 120

  Fly   218 NTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQYAFLYKYAHTMTEPSTGNRSHPGERGLFFTQH 282
            |.::::...:::||:    .:|.:.:   |.|:.|   |..|.....|.  :...||    |::.
Yeast   121 NALIFWDDNELQLLK----PSLVLER---IGKKEA---KEMHERIIKSI--KQIGGE----FSRV 169

  Fly   283 GLCYKL--YRWAVSTVMT------RQNLVPSEKQESE------DGPKLISALIPYWDMANHRPGK 333
            ...::.  :.:..|.:::      .|:...:|.:|.|      :..:.:.::||..||.|....|
Yeast   170 ATSFEFDNFAYIASIILSYSFDLEMQDSSVNENEEEETSEEELENERYLKSMIPLADMLNADTSK 234

  Fly   334 ITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVDPNNTK 384
            ..:.....|..|:..|...:...||.:..||:..|::||...|:|:.:.:|
Yeast   235 CNANLTYDSNCLKMVALRDIEKNEQVYNIYGEHPNSELLRRYGYVEWDGSK 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	62/294 (21%)
Setd3	NP_727144.1	Rubis-subs-bind	400..524	CDD:370401
RKM4	NP_010543.1	SET_SETD6	21..281	CDD:380955	58/278 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040