DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Setd3 and RKM2

DIOPT Version :9

Sequence 1:	NP_727144.1	Gene:	Setd3 / 31638	FlyBaseID:	FBgn0052732	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_010484.1	Gene:	RKM2 / 851779	SGDID:	S000002606	Length:	479	Species:	Saccharomyces cerevisiae

Alignment Length:	545	Identity:	103/545 - (18%)
Similarity:	174/545 - (31%)	Gaps:	202/545 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 KVEAFSAWAKDGGVHSEGLEIAIFPGYQLG---LRATRPLAKDELVLSVP--------------- 163
            ||:....|.|..........|:|....:.|   :.:...:.|:::::|||
Yeast     4 KVDVLLTWLKKSDKFYIAPNISICESPETGRGIVLSHGSIRKNDIIVSVPSSKQLNFHTILYHIS 68

  Fly   164 --------------RKLILSEENNSDCR----------LFGKMTQATHLNL-AYDLVIEKIRGE- 202
                          ||.|..|:|..:..          |:.::::...|:| ::.||...|..|
Yeast    69 KFNKELNIPGITIDRKPINYEDNIIEAENKAWADPRYGLYSELSKEFLLSLSSFQLVSFYILVEN 133

  Fly   203 -----------FSEWRPYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQYAFLYK 256
                       :|:|:|:.||.|:            ||.||...    |:..|...:: |..|.:
Yeast   134 FLLPKWTHNEIYSDWKPFFDVWPS------------MEELRSIP----AIWNCDPNSR-YHSLIE 181

  Fly   257 YAHTMTEPSTGNRSHPGERGLFFTQHGLCYKLYRW-AVSTVMTRQNLV--------PSEKQES-- 310
            |.     |:...:......||....         | .:|.|:.:.|.:        .|:|..|
Yeast   182 YL-----PAASRKHMARISGLVRED---------WETISEVVLKWNEIYGSLSCTKNSDKFTSDE 232

  Fly   311 -------------------------EDGPKLISALIPYWDMANHRPGKITSFYATVSRQLECTAQ 350
                                     ||.|...: |:||.|..||........|..:|.||....:
Yeast   233 LFSLFVHVYFIINSRCLYAKIPLKIEDSPSNFT-LVPYVDFMNHICESDLHCYPQLSPQLRSEGE 296

  Fly   351 EAV---------------NTGEQFFIYYGDRSNTDLLVHNGFVDPNNTKDYVNIRVGLSLTDALA 400
            ..:               |..|:.|:.||..||..||...|||...|..:|      |.::|
Yeast   297 NIIGIGQFTIRCGDHLYDNINEELFLNYGAHSNDFLLNEYGFVVDGNKWNY------LDISD--- 352

  Fly   401 AKRASILDKLNIRHTAELRVLPAPDFISKELLAFVRVFKMSAEQLDHWCSDLDRAGDLLH-IDCA 464
                              .::...|...||:..|:.       :.|:|........|:.: |..|
Yeast   353 ------------------EIIELIDDDKKEVKTFLL-------EHDYWGDYTINETDISYRIFVA 392

  Fly   465 LE---TDHETRTWQFLE-----------------DRLKLLLAVFNKEMHEADEVKELELKDGQEI 509
            |.   |..|.|..:|:|                 :.|..|.|.:.|.:.|..| |...|::...:
Yeast   393 LNYYVTRDERRVRKFIEGYISEDYFKPKISSVLKELLVSLTAKYTKTLSELTE-KVSNLENNLCL 456

  Fly   510 ELMLFLYRRLERSILAGALQYAQEH 534
            :.::.:|:        |.::...:|
Yeast   457 QNLITIYK--------GYIKILTQH 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	69/364 (19%)
Setd3	NP_727144.1	Rubis-subs-bind	400..524	CDD:370401	24/144 (17%)
RKM2	NP_010484.1	SET_SETD4	20..340	CDD:380954	68/351 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840