Protein Alignment Setd3 and RKM2

DIOPT Version :10

• Sequence 1: NP_727144.1
• Gene: Setd3 / 31638
• FlyBaseID: FBgn0052732
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_010484.1
• Gene: RKM2 / 851779
• SGDID: S000002606
• Length: 479
• Species: Saccharomyces cerevisiae
• Alignment Length: 545
• Identity: 103/545 - (18%)
• Similarity: 174/545 - (31%)
• Gaps: 202/545 - (37%)

  Fly   117 KVEAFSAWAKDGGVHSEGLEIAIFPGYQLG---LRATRPLAKDELVLSVP--------------- 163
            ||:....|.|..........|:|....:.|   :.:...:.|:::::|||
Yeast     4 KVDVLLTWLKKSDKFYIAPNISICESPETGRGIVLSHGSIRKNDIIVSVPSSKQLNFHTILYHIS 68

  Fly   164 --------------RKLILSEENNSDCR----------LFGKMTQATHLNL-AYDLVIEKIRGE- 202
                          ||.|..|:|..:..          |:.::::...|:| ::.||...|..|
Yeast    69 KFNKELNIPGITIDRKPINYEDNIIEAENKAWADPRYGLYSELSKEFLLSLSSFQLVSFYILVEN 133

  Fly   203 -----------FSEWRPYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQYAFLYK 256
                       :|:|:|:.||.|:            ||.||...    |:..|...:: |..|.:
Yeast   134 FLLPKWTHNEIYSDWKPFFDVWPS------------MEELRSIP----AIWNCDPNSR-YHSLIE 181

  Fly   257 YAHTMTEPSTGNRSHPGERGLFFTQHGLCYKLYRW-AVSTVMTRQNLV--------PSEKQES-- 310
            |.     |:...:......||....         | .:|.|:.:.|.:        .|:|..|
Yeast   182 YL-----PAASRKHMARISGLVRED---------WETISEVVLKWNEIYGSLSCTKNSDKFTSDE 232

  Fly   311 -------------------------EDGPKLISALIPYWDMANHRPGKITSFYATVSRQLECTAQ 350
                                     ||.|...: |:||.|..||........|..:|.||....:
Yeast   233 LFSLFVHVYFIINSRCLYAKIPLKIEDSPSNFT-LVPYVDFMNHICESDLHCYPQLSPQLRSEGE 296

  Fly   351 EAV---------------NTGEQFFIYYGDRSNTDLLVHNGFVDPNNTKDYVNIRVGLSLTDALA 400
            ..:               |..|:.|:.||..||..||...|||...|..:|      |.::|
Yeast   297 NIIGIGQFTIRCGDHLYDNINEELFLNYGAHSNDFLLNEYGFVVDGNKWNY------LDISD--- 352

  Fly   401 AKRASILDKLNIRHTAELRVLPAPDFISKELLAFVRVFKMSAEQLDHWCSDLDRAGDLLH-IDCA 464
                              .::...|...||:..|:.       :.|:|........|:.: |..|
Yeast   353 ------------------EIIELIDDDKKEVKTFLL-------EHDYWGDYTINETDISYRIFVA 392

  Fly   465 LE---TDHETRTWQFLE-----------------DRLKLLLAVFNKEMHEADEVKELELKDGQEI 509
            |.   |..|.|..:|:|                 :.|..|.|.:.|.:.|..| |...|::...:
Yeast   393 LNYYVTRDERRVRKFIEGYISEDYFKPKISSVLKELLVSLTAKYTKTLSELTE-KVSNLENNLCL 456

  Fly   510 ELMLFLYRRLERSILAGALQYAQEH 534
            :.::.:|:        |.::...:|
Yeast   457 QNLITIYK--------GYIKILTQH 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	69/364 (19%)
		Rubis-subs-bind	394..524	CDD:462737	25/150 (17%)
RKM2	NP_010484.1	SET_SETD4	20..340	CDD:380954	68/351 (19%)