Protein Alignment Setd3 and SETD3

DIOPT Version :10

• Sequence 1: NP_727144.1
• Gene: Setd3 / 31638
• FlyBaseID: FBgn0052732
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_115609.2
• Gene: SETD3 / 84193
• HGNCID: 20493
• Length: 594
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 185/553 - (33%)
• Similarity: 273/553 - (49%)
• Gaps: 81/553 - (14%)

  Fly     1 MGKNTKRNKKTKQQQQQPQQNGVTASASGTAVEDFEDQQAASSLPSLNGKKRSQLNKLVEELLDL 65
            |||  |...||     |....|.||:.|...:                      || |..|||..
Human     1 MGK--KSRVKT-----QKSGTGATATVSPKEI----------------------LN-LTSELLQK 35

  Fly    66 VEKQPANPNEEWKQYGQLQELLKQIMILEEPLSQAVCPQISD-SPDDQTRLAKVEAFSAWAKDGG 129
            .......|.:||::|.|::.|:::|...::.||.....:..| .||    |.|      ||.:.|
Human    36 CSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPD----LMK------WASENG 90

  Fly   130 VHSEGLEIAIFPGYQLGLRATRPLAKDELVLSVPRKLILSEENNSDCRL-----FGKMTQAT-HL 188
            ...||.|:..|.....||||||.:..:||.|.|||||:::.|:..:..|     ..::.||. ::
Human    91 ASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNI 155

  Fly   189 NLAYDLVIEKIRGEFSEWRPYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQYAF 253
            .||:.|:.|:.... |.|:|||..||::|:|.|||...::..|:.|.|......|.:..|:|||:
Human   156 ALAFHLLCERASPN-SFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAY 219

  Fly   254 LYKYAHTMTEPSTGNRSHPGERGL----FFTQHGLCYKLYRWAVSTVMTRQNLVPSEKQESEDGP 314
            .||...|          ||....|    .||     |:.||||||:||||||.:|     :|||.
Human   220 FYKVIQT----------HPHANKLPLKDSFT-----YEDYRWAVSSVMTRQNQIP-----TEDGS 264

  Fly   315 KLISALIPYWDMANHRPGKITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVD 379
            ::..||||.|||.||..|.||:.|.....:.||.|.:....|||.:|:||.|||.:.::|:||..
Human   265 RVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFF 329

  Fly   380 PNNTKDYVNIRVGLSLTDALAAKRASILDKLNIRHTAELRVLPAPDFISKELLAFVRVFKMSAEQ 444
            .||:.|.|.|::|:|.:|.|.|.:|.:|.:..|..::...:......||.:||||:|||.|:.|:
Human   330 DNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEE 394

  Fly   445 L-DHWCSD--LDRAGDLLHIDCALETDHETRTWQFLEDRLKLLLAVFNKEMHEADEV---KELEL 503
            | :|...|  :||...|.:.:..:..|:|.:.|.|||||..|||..:...:.|...|   .:|.:
Human   395 LKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSV 459

  Fly   504 KDGQEIELMLFLYRRLERSILAGALQ---YAQE 533
            :....|:|.|.....||:::.:.|:.   |.|:
Human   460 RAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQ 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	101/268 (38%)
		Rubis-subs-bind	394..524	CDD:462737	43/135 (32%)
SETD3	NP_115609.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		10/27 (37%)
		SET_SETD3	80..329	CDD:380953	106/279 (38%)
		Rubis-subs-bind	344..475	CDD:462737	41/130 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..594