DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Setd3 and SETD3

DIOPT Version :9

Sequence 1:	NP_727144.1	Gene:	Setd3 / 31638	FlyBaseID:	FBgn0052732	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_115609.2	Gene:	SETD3 / 84193	HGNCID:	20493	Length:	594	Species:	Homo sapiens

Alignment Length:	553	Identity:	185/553 - (33%)
Similarity:	273/553 - (49%)	Gaps:	81/553 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKNTKRNKKTKQQQQQPQQNGVTASASGTAVEDFEDQQAASSLPSLNGKKRSQLNKLVEELLDL 65
            |||  |...||     |....|.||:.|...:                      || |..|||..
Human     1 MGK--KSRVKT-----QKSGTGATATVSPKEI----------------------LN-LTSELLQK 35

  Fly    66 VEKQPANPNEEWKQYGQLQELLKQIMILEEPLSQAVCPQISD-SPDDQTRLAKVEAFSAWAKDGG 129
            .......|.:||::|.|::.|:::|...::.||.....:..| .||    |.|      ||.:.|
Human    36 CSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPD----LMK------WASENG 90

  Fly   130 VHSEGLEIAIFPGYQLGLRATRPLAKDELVLSVPRKLILSEENNSDCRL-----FGKMTQAT-HL 188
            ...||.|:..|.....||||||.:..:||.|.|||||:::.|:..:..|     ..::.||. ::
Human    91 ASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNI 155

  Fly   189 NLAYDLVIEKIRGEFSEWRPYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQYAF 253
            .||:.|:.|:.... |.|:|||..||::|:|.|||...::..|:.|.|......|.:..|:|||:
Human   156 ALAFHLLCERASPN-SFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAY 219

  Fly   254 LYKYAHTMTEPSTGNRSHPGERGL----FFTQHGLCYKLYRWAVSTVMTRQNLVPSEKQESEDGP 314
            .||...|          ||....|    .||     |:.||||||:||||||.:|     :|||.
Human   220 FYKVIQT----------HPHANKLPLKDSFT-----YEDYRWAVSSVMTRQNQIP-----TEDGS 264

  Fly   315 KLISALIPYWDMANHRPGKITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVD 379
            ::..||||.|||.||..|.||:.|.....:.||.|.:....|||.:|:||.|||.:.::|:||..
Human   265 RVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFF 329

  Fly   380 PNNTKDYVNIRVGLSLTDALAAKRASILDKLNIRHTAELRVLPAPDFISKELLAFVRVFKMSAEQ 444
            .||:.|.|.|::|:|.:|.|.|.:|.:|.:..|..::...:......||.:||||:|||.|:.|:
Human   330 DNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEE 394

  Fly   445 L-DHWCSD--LDRAGDLLHIDCALETDHETRTWQFLEDRLKLLLAVFNKEMHEADEV---KELEL 503
            | :|...|  :||...|.:.:..:..|:|.:.|.|||||..|||..:...:.|...|   .:|.:
Human   395 LKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSV 459

  Fly   504 KDGQEIELMLFLYRRLERSILAGALQ---YAQE 533
            :....|:|.|.....||:::.:.|:.   |.|:
Human   460 RAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQ 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	101/268 (38%)
Setd3	NP_727144.1	Rubis-subs-bind	400..524	CDD:370401	40/129 (31%)
SETD3	NP_115609.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		10/27 (37%)
		SET_SETD3	80..329	CDD:380953	106/279 (38%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:30626964, ECO:0000269\|PubMed:30785395, ECO:0000269\|PubMed:31388018, ECO:0000269\|PubMed:31911441, ECO:0000269\|PubMed:31993215, ECO:0000269\|PubMed:32503840, ECO:0000269\|Ref.12, ECO:0007744\|PDB:3SMT, ECO:0007744\|PDB:6ICT, ECO:0007744\|PDB:6ICV, ECO:0007744\|PDB:6JAT, ECO:0007744\|PDB:6MBJ, ECO:0007744\|PDB:6MBK, ECO:0007744\|PDB:6MBL, ECO:0007744\|PDB:6OX0, ECO:0007744\|PDB:6OX1, ECO:0007744\|PDB:6OX2, ECO:0007744\|PDB:6OX3, ECO:0007744\|PDB:6OX4, ECO:0007744\|PDB:6OX5, ECO:0007744\|PDB:6V62, ECO:0007744\|PDB:6V63, ECO:0007744\|PDB:6WK1, ECO:0007744\|PDB:6WK2	104..106		0/1 (0%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:30626964, ECO:0000269\|PubMed:30785395, ECO:0000269\|PubMed:31388018, ECO:0000269\|PubMed:31911441, ECO:0000269\|PubMed:31993215, ECO:0000269\|PubMed:32503840, ECO:0000269\|Ref.12, ECO:0007744\|PDB:3SMT, ECO:0007744\|PDB:6ICT, ECO:0007744\|PDB:6ICV, ECO:0007744\|PDB:6JAT, ECO:0007744\|PDB:6MBJ, ECO:0007744\|PDB:6MBK, ECO:0007744\|PDB:6MBL, ECO:0007744\|PDB:6OX0, ECO:0007744\|PDB:6OX1, ECO:0007744\|PDB:6OX2, ECO:0007744\|PDB:6OX3, ECO:0007744\|PDB:6OX4, ECO:0007744\|PDB:6OX5, ECO:0007744\|PDB:6V62, ECO:0007744\|PDB:6V63, ECO:0007744\|PDB:6WK1, ECO:0007744\|PDB:6WK2	275..279		2/3 (67%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:30626964, ECO:0000269\|PubMed:30785395, ECO:0000269\|PubMed:31388018, ECO:0000269\|PubMed:31911441, ECO:0000269\|PubMed:31993215, ECO:0000269\|PubMed:32503840, ECO:0000269\|Ref.12, ECO:0007744\|PDB:3SMT, ECO:0007744\|PDB:6ICT, ECO:0007744\|PDB:6ICV, ECO:0007744\|PDB:6JAT, ECO:0007744\|PDB:6MBJ, ECO:0007744\|PDB:6MBK, ECO:0007744\|PDB:6MBL, ECO:0007744\|PDB:6OX0, ECO:0007744\|PDB:6OX1, ECO:0007744\|PDB:6OX2, ECO:0007744\|PDB:6OX3, ECO:0007744\|PDB:6OX4, ECO:0007744\|PDB:6OX5, ECO:0007744\|PDB:6V62, ECO:0007744\|PDB:6V63, ECO:0007744\|PDB:6WK1, ECO:0007744\|PDB:6WK2	325..327		0/1 (0%)
		Rubis-subs-bind	350..475	CDD:401276	38/124 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158344
Domainoid	1	1.000	137	1.000	Domainoid score	I4913
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3310
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55129
OrthoDB	1	1.010	-	-		D407981at33208
OrthoFinder	1	1.000	-	-		FOG0001685
OrthoInspector	1	1.000	-	-		oto90621
orthoMCL	1	0.900	-	-		OOG6_101154
Panther	1	1.100	-	-	LDO	PTHR13271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	1	1.000	-	-		X3007
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800