Protein Alignment Setd3 and SETD6

DIOPT Version :9

• Sequence 1: NP_727144.1
• Gene: Setd3 / 31638
• FlyBaseID: FBgn0052732
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001153777.1
• Gene: SETD6 / 79918
• HGNCID: 26116
• Length: 473
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 109/499 - (21%)
• Similarity: 200/499 - (40%)
• Gaps: 107/499 - (21%)

  Fly    98 SQAVCPQISDSPDDQTRLAKVEAFSAWA-------------KDGGVHSEG----------LEIAI 139
            :||..|::: .|.|...|..|..|.:|.             :.||..:.|          .::|:
Human     3 TQAKRPRVA-GPVDGGDLDPVACFLSWCRRVGLELSPKVSERAGGRRTRGGARAALTSPPAQVAV 66

  Fly   140 -----FPGYQLGLRATRPLAKDELVLSVPRKLILSEENNSDCRLFGKM--------TQATHLNLA 191
                 ..||  |:.|...:...||:..|||..:||:..   |.:.|.:        :|:..:.|.
Human    67 SRQGTVAGY--GMVARESVQAGELLFVVPRAALLSQHT---CSIGGLLERERVALQSQSGWVPLL 126

  Fly   192 YDLVIEKIRGEFSEWRPYIDVLP--AKYNTVLYFTTKQME-LLRGTAAAALAMRQCRVIAKQYAF 253
            ..| :.:::...|.||||..:.|  .:....:::..::.. ||:||.......:....|..:|
Human   127 LAL-LHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEY-- 188

  Fly   254 LYKYAHTMTEPSTGNRSHPGERGLFFTQHGLCYKLYRWAVSTVMTRQNLVPSEKQESEDGPKLIS 318
                 .::..|..  .:||.    .|:......:||...|:.||......|.|::|.|..|. ..
Human   189 -----QSIVLPFM--EAHPD----LFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPN-SP 241

  Fly   319 ALIPYWDMANHRPGKITSFYATVSRQLEC---TAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVD- 379
            .::|..|:.||    :.:..|.:.....|   .|.:.:..|.:.|..||..:|..|:...|||:
Human   242 VMVPAADILNH----LANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFVEP 302

  Fly   380 -PNNTKDYVNIRVGLSLTDA------------LAAKRASILDKLNIRHTAELRVLPAPDFIS-KE 430
             |:||.|..:|:: :::.:|            |..:|...|.||.:.......|:...:.:: :|
Human   303 YPDNTDDTADIQM-VTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREEVLTEEE 366

  Fly   431 LLAFVRVFKMSAEQLDHWCSDLDRAGDLLHIDCALETDHETR---TW-QFLEDRLKLLLAVF--- 488
            |...::|..|.||:... ..|.|..||....:.:|...:..:   :| |.|::.:.|.|..:
Human   367 LTTTLKVLCMPAEEFRE-LKDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSVLLTLQTYATD 430

  Fly   489 ---------NKEMHEA---DEVKELELKDGQEIELMLFLYRRLE 520
                     |||::..   .|.:.|:::.||:    :.|::.||
Human   431 LKTDQGLLSNKEVYAKLSWREQQALQVRYGQK----MILHQLLE 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	62/300 (21%)
		Rubis-subs-bind	400..524	CDD:370401	31/141 (22%)
SETD6	NP_001153777.1	SET	<247..286	CDD:279228	8/42 (19%)
		Rubis-subs-bind	338..465	CDD:286371	28/131 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940