DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Setd3 and setd3

DIOPT Version :9

Sequence 1:	NP_727144.1	Gene:	Setd3 / 31638	FlyBaseID:	FBgn0052732	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_012823880.1	Gene:	setd3 / 549331	XenbaseID:	XB-GENE-1016707	Length:	582	Species:	Xenopus tropicalis

Alignment Length:	555	Identity:	187/555 - (33%)
Similarity:	269/555 - (48%)	Gaps:	85/555 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKNTKRNKKTKQQQQQPQQNGVTASASGTAVEDFEDQQAASSLPSLNGKKRSQLNKLVEELLDL 65
            |||  |...||::            |.||.|.       |.|....||         |:.|||..
Frog     1 MGK--KSRVKTQK------------SGSGAAA-------AVSPKEMLN---------LISELLQK 35

  Fly    66 VEKQPANPNEEWKQYGQLQELLKQIMILEEPLSQAVCPQISDSPDDQTRLAKVEAFSAWAKDGGV 130
            .....:.|..||::|.|::.|:::|...:..||...         |..|.........|.|:.|.
Frog    36 CSNPNSTPGREWEEYVQIRGLVEKIRKKQRGLSVVF---------DGKREDYFPELMEWCKENGA 91

  Fly   131 HSEGLEIAIFPGYQLGLRATRPLAKDELVLSVPRKLILSEEN---------NSDCRLFGKMTQAT 186
            .::|.|:..||....||:|||.:..:||.|.|||||:::.|:         .|..|:...|...|
Frog    92 STDGFELVEFPEEGFGLKATREIKAEELFLWVPRKLLMTVESAKGSVLGPLYSQDRILQAMGNIT 156

  Fly   187 HLNLAYDLVIEKIRGEFSEWRPYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQY 251
               ||:.|:.|:.... |.|.|||..||.:|:|.|||...:::.|:.|.|......|.:..|:||
Frog   157 ---LAFHLLCERADPN-SFWLPYIKTLPNEYDTPLYFNEDEVQYLQSTQAILDVFSQYKNTARQY 217

  Fly   252 AFLYKYAHTMTEPSTGNRSHPGERGL----FFTQHGLCYKLYRWAVSTVMTRQNLVPSEKQESED 312
            |:.||...|          ||....|    .||     :..||||||:||||||.:|     :||
Frog   218 AYFYKVIQT----------HPNANKLPLKDSFT-----FDDYRWAVSSVMTRQNQIP-----TED 262

  Fly   313 GPKLISALIPYWDMANHRPGKITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSNTDLLVHNGF 377
            |.::..||||.|||.||..|.||:.|.....:.||.|.:...:|||.:|:||.|||.:.::||||
Frog   263 GSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFKSGEQIYIFYGTRSNAEFVIHNGF 327

  Fly   378 VDPNNTKDYVNIRVGLSLTDALAAKRASILDKLNIRHTA--ELRVLPAPDFISKELLAFVRVFKM 440
            ...||..|.|.|::|:|.:|.|.|.:|.:|.:..|..::  .|.|...|  ||.:||||:|||.|
Frog   328 FFENNLHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHVTEPP--ISAQLLAFLRVFCM 390

  Fly   441 SAEQL-DHWCSD--LDRAGDLLHIDCALETDHETRTWQFLEDRLKLLLAVFNKEMHEADEVKELE 502
            :.::| .|...|  :|:...|.:.:..:..::|.:.|.|||.|..|||..:...:.  |:.|.||
Frog   391 NEDELKGHLIGDHAIDKIFTLGNSEFPVSWENEIKLWTFLEARASLLLKTYKTTVE--DDNKVLE 453

  Fly   503 LKDGQEIELMLFLYRRLERSILAGALQYAQEHRKV 537
            ..|......|....||:|:.||..||:.|.::||:
Frog   454 QPDMTFHSAMAIKLRRVEKEILEKALKSASDNRKL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	101/271 (37%)
Setd3	NP_727144.1	Rubis-subs-bind	400..524	CDD:370401	40/128 (31%)
setd3	XP_012823880.1	SET_SETD3	80..329	CDD:380953	102/272 (38%)
setd3	XP_012823880.1	Rubis-subs-bind	350..475	CDD:370401	40/128 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5041
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	249	1.000	Inparanoid score	I3168
OMA	1	1.010	-	-		QHG55129
OrthoDB	1	1.010	-	-		D407981at33208
OrthoFinder	1	1.000	-	-		FOG0001685
OrthoInspector	1	1.000	-	-		oto104419
Panther	1	1.100	-	-	LDO	PTHR13271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	1	1.000	-	-		X3007
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110