Protein Alignment Setd3 and SETD4

DIOPT Version :9

• Sequence 1: NP_727144.1
• Gene: Setd3 / 31638
• FlyBaseID: FBgn0052732
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_059134.1
• Gene: SETD4 / 54093
• HGNCID: 1258
• Length: 440
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 98/423 - (23%)
• Similarity: 160/423 - (37%)
• Gaps: 70/423 - (16%)

  Fly   124 WAKDGGVHSEGLEIAIFPGYQLGLRATRPLAKDELVLSVPRKLILSEENNSDCRLFGKMTQ---- 184
            |.|........|..|.|||...||.:...|.:.::::|:|...:|:.:......|...:|:
Human    39 WLKARKFQDSNLAPACFPGTGRGLMSQTSLQEGQMIISLPESCLLTTDTVIRSYLGAYITKWKPP 103

  Fly   185 -ATHLNLAYDLVIEKIRGEFSEWRPYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIA 248
             :..|.|...||.||..|..|.|:||:::||..|...:....:.:.||..:..|....::..|
Human   104 PSPLLALCTFLVSEKHAGHRSLWKPYLEILPKAYTCPVCLEPEVVNLLPKSLKAKAEEQRAHV-- 166

  Fly   249 KQYAFLYKYAHTMTEPSTGNRSHPGERGLFFTQHGL---------CYKLYRWAVSTVMTRQNLVP 304
             |..|                  ...|..|.:...|         .|....||..||.||...:.
Human   167 -QEFF------------------ASSRDFFSSLQPLFAEAVDSIFSYSALLWAWCTVNTRAVYLR 212

  Fly   305 SEKQESEDGPKLISALIPYWDMANHRPG-KITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSN 368
            ..::|.........||.||.|:.||.|. ::.:.:...:...|..........|:.||.||...|
Human   213 PRQRECLSAEPDTCALAPYLDLLNHSPHVQVKAAFNEETHSYEIRTTSRWRKHEEVFICYGPHDN 277

  Fly   369 TDLLVHNGFVDPNNTKD--YVNIRV---GLSLTDALAAKRASILDKLNIRHTAELRVLPAPDFIS 428
            ..|.:..|||..:|...  ||:..:   .|..||....|:.|||..    |.....:....|..|
Human   278 QRLFLEYGFVSVHNPHACVYVSREILVKYLPSTDKQMDKKISILKD----HGYIENLTFGWDGPS 338

  Fly   429 KELLAFVRVFKMSAEQLDHWCSDLDRAGDLLHIDCALETDHETR-------TWQFLEDRLKLLLA 486
            ..||..:::..:.||:...|...|  .|:::.     :|:.:|.       .:.|:|:    ..|
Human   339 WRLLTALKLLCLEAEKFTCWKKVL--LGEVIS-----DTNEKTSLDIAQKICYYFIEE----TNA 392

  Fly   487 VFNKEMHEADE----VKELELKDG---QEIELM 512
            |..|..|..||    :.:|.|.:.   :|::::
Human   393 VLQKVSHMKDEKEALINQLTLVESLWTEELKIL 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	63/268 (24%)
		Rubis-subs-bind	400..524	CDD:370401	27/127 (21%)
SETD4	NP_059134.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		SET	<210..273	CDD:279228	13/62 (21%)
		Rubis-subs-bind	317..425	CDD:286371	26/122 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840