DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Setd3 and set13

DIOPT Version :9

Sequence 1:	NP_727144.1	Gene:	Setd3 / 31638	FlyBaseID:	FBgn0052732	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_594072.2	Gene:	set13 / 2543346	PomBaseID:	SPAC688.14	Length:	468	Species:	Schizosaccharomyces pombe

Alignment Length:	477	Identity:	95/477 - (19%)
Similarity:	174/477 - (36%)	Gaps:	91/477 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LAKVEAFSAWA--KDGGVHSEGLEI----AIFPGYQLGLRATRPLAKDELVLSVPRKLILSEENN 173
            |.:.|:...||  ||....||.:.:    .:.....:|..|...:.:||.::|..:..:|...|:
pombe     2 LKQAESMLKWAIEKDNYTTSEKIGLNDYRHVHESLGIGFIALEDIKEDEKLVSFKKDSVLCLTNS 66

  Fly   174 SDCRLFGKMTQATHLNLAYDLVIEKIRGEFSEWRPYIDVLPAKYNTVLYF---TTKQMELLRGTA 235
            ...:|....:..:...|...:..|..... |.||||:.:.|.|......|   ..|:..|||||.
pombe    67 DLAQLPEVQSLPSWAALLLVMATENASPN-SFWRPYLSIFPTKERITSPFYWDENKKDALLRGTV 130

  Fly   236 AAA---------LAMRQCRVIAKQY--------------------AFLYKYAHTMTEPSTGNRSH 271
            ..:         |.:.:...|.|.|                    |:.:....|.:..|..|...
pombe   131 LESNEDCNEITQLWIDRIEPIIKLYPNRFSQVSYEDFLRMSAVMLAYSFDIEKTKSPISNENEKS 195

  Fly   272 PGERGLFFTQHGLCYKLYRWAVS---TVMTRQNL------VPSEKQ----ESE-DGPKLISALIP 322
            ..|..:...::|...|....:.:   ..:..|:|      |.||.:    ||| |..:|..|:.|
pombe   196 AAETSIKEDKNGDAAKKNEGSANQDDEKLHSQSLVGNNCEVNSEDEFSDLESEVDPDELEKAMCP 260

  Fly   323 YWDMANHRPGKITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVDPNNT-KDY 386
            ..||.|............::..|...|...:..|||.:..||:..|::|....||.....| .|:
pombe   261 ISDMFNGDDELCNIRLYDINGTLTMIATRDIKKGEQLWNTYGELDNSELFRKYGFTKKKGTPHDF 325

  Fly   387 VNI-----------RVGLSLTDALAAKRASILDKLNIRHTAELR-VLPAPDFISKEL-LAFVRVF 438
            |.|           ::|....:|    |..:|.:..:.:..|.. .....|...||: ||||.
pombe   326 VLIKKEHWLPEYIEKLGFEEVEA----RLELLCREELLYNLEGDFTFSKADLTFKEICLAFVL-- 384

  Fly   439 KMSAEQLDHWCSDLDRAGDLLHIDCA--LETDHETRTWQFLEDRLKLLLAVFNKEMHEADEVKEL 501
                         :::..:|:.:...  ::..|..:..:.:|.|:.:...:.:.:..:.:..|
pombe   385 -------------MEKEKELISVPSKSDIKPKHYRKLLKIIEKRINMYPKISDPKNFDEENAK-- 434

  Fly   502 ELKDGQEIELMLFLYRRLERSI 523
            .|.:| ||:::..|..:::.::
pombe   435 TLIEG-EIDILQNLSAKVKEAL 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	67/310 (22%)
Setd3	NP_727144.1	Rubis-subs-bind	400..524	CDD:370401	20/128 (16%)
set13	NP_594072.2	SET	<252..302	CDD:279228	11/49 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	1	1.000	-	-		X3007
TreeFam	0	0.000	Not matched by this tool.
	3	2.940