DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Setd3 and set10

DIOPT Version :9

Sequence 1:	NP_727144.1	Gene:	Setd3 / 31638	FlyBaseID:	FBgn0052732	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_595446.1	Gene:	set10 / 2539820	PomBaseID:	SPBC1709.13c	Length:	547	Species:	Schizosaccharomyces pombe

Alignment Length:	414	Identity:	104/414 - (25%)
Similarity:	177/414 - (42%)	Gaps:	82/414 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 ATRPLAKDELVLSVPRKLILS-----EE------NNSDCRLFGKMTQATHLNLAYDLVIEKIRGE 202
            |...:|.|:|::|.|.:..::     ||      |...|.        .|:.|...|.:|.::|.
pombe    38 AQNDIAPDQLLISCPFEYAITYNKAKEELKKLNPNFESCN--------PHITLCTFLALESLKGI 94

  Fly   203 FSEWRPYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQYAFLYKYAHTMT-EPST 266
            .|:|..||:.||..:||.|||.......|..|.|.:.|..:..:      :.::|...:: .||
pombe    95 QSKWYGYIEYLPKTFNTPLYFNENDNAFLISTNAYSAAQERLHI------WKHEYQEALSLHPS- 152

  Fly   267 GNRSHPGERGLFFTQHGLCYKLYRWAVSTVMTR---QNLVPSEKQESEDGPKLISALIPYWDMAN 328
                 |.||   ||     :.||.|:.:...:|   .||:   .::||..|    .|:|..|..|
pombe   153 -----PTER---FT-----FDLYIWSATVFSSRCFSSNLI---YKDSESTP----ILLPLIDSLN 197

  Fly   329 HRPGK----ITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVDPNNTKDYVNI 389
            |:|.:    .:.|....|.||  .:||.|..|.|.|..||.:.|.:||:..||..|:|..|.|.:
pombe   198 HKPKQPILWNSDFQDEKSVQL--ISQELVAKGNQLFNNYGPKGNEELLMGYGFCLPDNPFDTVTL 260

  Fly   390 RVGLSLTDALAAKRASILDK-LNIRHTAELRVLP-APD-FISKELLAFVRVFKMSAEQLDHWCSD 451
            :|.:........::|:||:. ...:.:..:..|| :|| .|.:::|..:.|...|:.:|....:.
pombe   261 KVAIHPDLPHKDQKAAILENDCQFQLSNLVFFLPKSPDKEIFQKILQCLAVVTASSLELRKLTAH 325

  Fly   452 LDRAGDLLHIDCALETDHETRTWQFLEDRLKLLLAVFNKEMHEADEVKELELKDGQEI------E 510
            | ..|||.....:|....::         |::||...       |...:|.||...::      :
pombe   326 L-LTGDLASYVPSLRGQIKS---------LEVLLMYI-------DSRADLLLKSNPQVSPTSERQ 373

  Fly   511 LMLFLYRRLERSILAGALQYAQEH 534
            :...:||..:.:||..::.|.:.:
pombe   374 VWAKIYRDSQINILQDSITYVKNY 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	69/247 (28%)
Setd3	NP_727144.1	Rubis-subs-bind	400..524	CDD:370401	26/132 (20%)
set10	NP_595446.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	57	1.000	Domainoid score	I3124
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001685
OrthoInspector	1	1.000	-	-		oto101593
orthoMCL	1	0.900	-	-		OOG6_101154
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	1	1.000	-	-		X3007
TreeFam	1	0.960	-	-
	9	8.700