DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Setd3 and set11

DIOPT Version :9

Sequence 1:	NP_727144.1	Gene:	Setd3 / 31638	FlyBaseID:	FBgn0052732	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_588349.1	Gene:	set11 / 2539232	PomBaseID:	SPCC1223.04c	Length:	381	Species:	Schizosaccharomyces pombe

Alignment Length:	435	Identity:	93/435 - (21%)
Similarity:	155/435 - (35%)	Gaps:	81/435 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 VEAFSAWAKDGG--VHSEGLEIAIFPGYQLGLRATRPLAKDELVLSVPRKLILSEENNSDCRLFG 180
            :|:..:|.|..|  || ..||.::.|.....:.|...:.::.::|.:|..:::   |...|..:.
pombe     7 IESEVSWVKSKGAFVH-PSLEFSVIPDAGSCVLANNDINENTVLLKLPPNILI---NKRTCSRYS 67

  Fly   181 KMTQATHLNLAYDLVIEKIRGEFSEWRPYIDVLPAKYN---TVLYFTTKQMELLRGTAAAALAMR 242
            ...:.|.......|:.|.:.........|...||..::   ..|........:|......:|..|
pombe    68 FRDKLTSFQFLSWLISEDVHSNLEISPYYTKALPQGFSFHPVTLTSDHPLWSILPDEVRNSLLER 132

  Fly   243 QCRVIAKQYAFLYKYAHTMTEPSTGNRSHPGERGLFFTQHGLCYKLYRWAVSTVMTRQNLVPSEK 307
            : .|:|..|..:.|:. ::.:|:                       ::|....|.||.....:..
pombe   133 K-NVMAFDYEQVKKFV-SVDQPT-----------------------FQWGWLCVNTRCLYYDTGS 172

  Fly   308 QESEDGPKLISALIPYWDMANHRPGKITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSNTDLL 372
            :.:||.    ..|.|.::..||.|...|:...| ...:...:...::.|||.|:.||...|..|.
pombe   173 KNTEDH----LTLAPIFEYFNHSPEAQTALINT-RGTITIKSTRRIDKGEQIFLCYGPHGNDKLF 232

  Fly   373 VHNGFVDPNNTKDYVNIRVGLSLTDALAAKRASIL-------DKLNIRHTAELRVLPAPDFISKE 430
            ...||...||.    ||.:.|.........:.|.|       |.....|.|..|.|..
pombe   233 TEYGFCLSNNP----NISIQLDRFIEFDKWQQSFLQDHGYWNDYTCSLHGASFRTLVG------- 286

  Fly   431 LLAFVRVFKMS-AEQLDHWCSDLDRAGDLLHIDCALETDHETRTWQFLEDRLKLLLAVFNKEMHE 494
                ||...:| :|:|:....|..|. .|.:|:   .....:|..|.:||.||   .|..:.:.|
pombe   287 ----VRTLLVSPSEKLNDASYDQTRR-VLQYIN---GFSDGSRDRQDVEDYLK---KVLQELLCE 340

  Fly   495 ADEVKE--LELKDGQEIEL---MLFLYRRLERSILAGALQYAQEH 534
            |:|.||  ..:.||..:.:   .|:..|.:       ..||..||
pombe   341 AEECKEKVKGISDGSYVFICAEQLWKDRIM-------CCQYLMEH 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	51/263 (19%)
Setd3	NP_727144.1	Rubis-subs-bind	400..524	CDD:370401	32/136 (24%)
set11	NP_588349.1	SET	<164..230	CDD:214614	17/70 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940