Protein Alignment Setd3 and set-27

DIOPT Version :9

• Sequence 1: NP_727144.1
• Gene: Setd3 / 31638
• FlyBaseID: FBgn0052732
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_497604.2
• Gene: set-27 / 190607
• WormBaseID: WBGene00022173
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 141/539 - (26%)
• Similarity: 226/539 - (41%)
• Gaps: 81/539 - (15%)

  Fly    40 AASSLPSLNGKKRSQLNKLVEELLDLVEKQPANPNEEWKQYGQLQELLKQIMILEEPLSQAVCPQ 104
            |.|....|..:...::..|.||.|.  ::.|:|..|.||::.:::.:|..::.::..|.
 Worm     2 APSPTAELEDQILGKIATLFEETLS--KQPPSNIVELWKEHVEIRRILNDVISIQAKLG------ 58

  Fly   105 ISDSPDDQTRLA-------KVEAFSAWAKDGGVHSEGLEIAIFPGYQLGLRATRPLAKDELVLSV 162
                 |...|||       .::.|.|||...|:....:.|.......|.|:||.|:.|..:|..|
 Worm    59 -----DTDERLANSKRDADSIKTFLAWADGVGIARNNVTIGSTKTAGLSLQATGPIPKSHIVARV 118

  Fly   163 PRKLILSEENNSDCRLFGKMTQ-------ATHLNLAYDLVIEKIRGEFSEWRPYIDVLPAKYNTV 220
            ||..:::.:......|..|..:       ..::.||..|..:.|:.|.|:|:.||.:||..:.|.
 Worm   119 PRHAMITLDLAKKSSLLKKAFEKDPIVGGMDNVGLALFLACQWIQNEKSKWKSYISILPTTFPTP 183

  Fly   221 LYFTTKQMELLRGTAAAALAMRQCRVIAKQYA-FLYKYAHTMTEPSTGNRS---HPGERGLF--- 278
            |:::.:|:..|:.:.....|:...|.|::|:. ||...|......:...|.   :..|..:|
 Worm   184 LFYSEEQLLQLKPSPIFEEAILFYRTISRQFCYFLLAIAKNKIYEAAQRRKDARNAMETPIFYNV 248

  Fly   279 -FTQHGLCYKLYRWAVSTVMTRQNLVPSEKQESEDG-PKLISALIPYWDMANHRPGKITSFYATV 341
             |.......|||.|||..|.||.|:||||.|..||| |.:|.||||..|||||. ..:|......
 Worm   249 PFNVANFTPKLYFWAVGVVTTRVNMVPSENQVGEDGNPVIIPALIPVLDMANHE-NVLTDVLTEP 312

  Fly   342 SRQLECTAQEA----------VNTGEQFFIYYGDRSNTDLLVHNGFVDPNNTK-DYVNIRVGLSL 395
            ...|.|.:.|.          |..|.:..|:||.||..:.|:|||||...:.| |.:.:::|:..
 Worm   313 IEDLVCYSPEEECAVITSHCDVKAGNEVTIFYGCRSKGEHLLHNGFVPIYHGKFDVLKLKIGIPK 377

  Fly   396 TDALAAKRASILDKL--------NIRHTAELRVLPAPDFISKELLAFVRVFKMSAEQLDHWCSDL 452
            ||.....:..::.|.        ||.|.........|  ...:||.|..:| :|....:
 Worm   378 TDKTLDAKKKLIQKFVKKVYCAGNIFHVDLYNYHEQP--FPLDLLMFAAIF-VSTTPTE------ 433

  Fly   453 DRAGDLLHIDCALETDHETRTWQFLEDRLKLLLAVFNKEMHEADEVKELELKDGQEIELMLFLYR 517
                     :.....::..:..:||:.|..||...:.... :|.::||:.: ||....|     :
 Worm   434 ---------EAVSAPENRKKGLEFLKTRFSLLKRSYESSF-DASKLKEIGI-DGDSARL-----K 482

  Fly   518 RLERSILAGALQYAQEHRK 536
            ..|..||..||.|.:...|
 Worm   483 SAELDILQLALNYCETLEK 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	88/284 (31%)
		Rubis-subs-bind	400..524	CDD:370401	22/131 (17%)
set-27	NP_497604.2	SET_SETD3	76..360	CDD:380953	89/284 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166023
Domainoid	1	1.000	93	1.000	Domainoid score	I4785
eggNOG	1	0.900	-	-		E1_KOG1337
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I3112
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55129
OrthoDB	1	1.010	-	-		D407981at33208
OrthoFinder	1	1.000	-	-		FOG0001685
OrthoInspector	1	1.000	-	-		oto17852
orthoMCL	1	0.900	-	-		OOG6_101154
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1321
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.700