DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht11 and Chil3

DIOPT Version :9

Sequence 1:	NP_572361.1	Gene:	Cht11 / 31630	FlyBaseID:	FBgn0029913	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_034022.2	Gene:	Chil3 / 12655	MGIID:	1330860	Length:	398	Species:	Mus musculus

Alignment Length:	405	Identity:	117/405 - (28%)
Similarity:	186/405 - (45%)	Gaps:	66/405 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLGIQTGEVHKVGQRLVCYYAS-------DGTHNLSLLDVPGD----LCTHINIGPATLDNATIV 107
            ||.:|.|..:    :|:|||.|       :|:..      ||:    ||||:....|.:.|..|.
Mouse    13 LLNVQLGSSY----QLMCYYTSWAKDRPIEGSFK------PGNIDPCLCTHLIYAFAGMQNNEIT 67

  Fly   108 LPDTLRQVLQNDTRSFRA------AHPQVHLLLWIGGADSGRS-FALMVANHAMRKLFLRSLREI 165
            ...      :.|.|.:.|      .:.::..||.|||...|.: |:.||:....|::|::|:...
Mouse    68 YTH------EQDLRDYEALNGLKDKNTELKTLLAIGGWKFGPAPFSAMVSTPQNRQIFIQSVIRF 126

  Fly   166 LRTYPSLDGIDLDWEFPSAY---DRERMHLSQLLYEIRTEWRREKRTNDILSLAVAAPEG----I 223
            ||.| :.||::|||::|.:.   .:::...|.|:.|:|..:..|....||..|.:.:...    :
Mouse   127 LRQY-NFDGLNLDWQYPGSRGSPPKDKHLFSVLVKEMRKAFEEESVEKDIPRLLLTSTGAGIIDV 190

  Fly   224 AFYAYDIREINLYADYVNLMSYDFHFYREDTPFTGLNAPLYARSQERSLMATFNINYTVQWWLKS 288
            ....|.|.|::...||:.:|:||.|..::.  :||.|:|||....:....|..|::..:.:|...
Mouse   191 IKSGYKIPELSQSLDYIQVMTYDLHDPKDG--YTGENSPLYKSPYDIGKSADLNVDSIISYWKDH 253

  Fly   289 GLEPQRLVVGLPTYGHSFTLVNPLNHRIGAPASGYGKCG----QLGFTTLTETC----ECVTKFF 345
            |...::|:||.|.|||:|.|.:|....||||....|..|    :.|.....|.|    |..|:.
Mouse   254 GAASEKLIVGFPAYGHTFILSDPSKTGIGAPTISTGPPGKYTDESGLLAYYEVCTFLNEGATEV- 317

  Fly   346 KPNLSYDAESCSPYLSALQEWISYENQTSIACKANYVKSLNLGGVMVFSLNTDDLKNSCSIMPNL 410
                 :||....||.....||:.|:|..|...||.::|..||||.:|:.|:.||...|
Mouse   318 -----WDAPQEVPYAYQGNEWVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGS------- 370

  Fly   411 KYSEKPVFPLTQAIK 425
             :..:..||||..:|
Mouse   371 -FCHQRHFPLTSTLK 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht11	NP_572361.1	Glyco_18	68..398	CDD:214753	105/362 (29%)
Cht11	NP_572361.1	GH18_chitinase-like	69..428	CDD:299167	113/390 (29%)
Chil3	NP_034022.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	113/390 (29%)
		Glyco_18	26..365	CDD:214753	104/359 (29%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/6 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930