Protein Alignment Cht11 and CHI3L1

DIOPT Version :9

• Sequence 1: NP_572361.1
• Gene: Cht11 / 31630
• FlyBaseID: FBgn0029913
• Length: 432
• Species: Drosophila melanogaster
• Sequence 2: NP_001267.2
• Gene: CHI3L1 / 1116
• HGNCID: 1932
• Length: 383
• Species: Homo sapiens
• Alignment Length: 416
• Identity: 131/416 - (31%)
• Similarity: 204/416 - (49%)
• Gaps: 75/416 - (18%)

  Fly    52 LGLLGIQTGEVHKV------GQRLVCYYAS-------DGTHNLSLLDVPGDLCTHINIGPATLDN 103
            :|:...|||.|..|      ..:|||||.|       ||:.....||  ..|||||....|.:.|
Human     1 MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALD--RFLCTHIIYSFANISN 63

  Fly   104 ATIVLPDTLRQVLQNDT------RSFRAAHPQVHLLLWIGGADSG-RSFALMVANHAMRKLFLRS 161
            ..|   ||..   .||.      .:.:..:|.:..||.:||.:.| :.|:.:.:|...|:.|::|
Human    64 DHI---DTWE---WNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKS 122

  Fly   162 LREILRTYPSLDGIDLDWEFPSAYDRERMHLSQLLYEIRTEWRREKRTND---ILSLAVAAPEGI 223
            :...|||: ..||:||.|.:|..  |::.|.:.|:.|::.|:.:|.:...   :||.|::|.:..
Human   123 VPPFLRTH-GFDGLDLAWLYPGR--RDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVT 184

  Fly   224 AFYAYDIREINLYADYVNLMSYDFHFYREDTPFTGLNAPLYARSQERSLMATFNINYTVQWWLKS 288
            ...:|||.:|:.:.|::::|:||||.....|  ||.::||:...::.|.....|.:|.|.:.|:.
Human   185 IDSSYDIAKISQHLDFISIMTYDFHGAWRGT--TGHHSPLFRGQEDASPDRFSNTDYAVGYMLRL 247

  Fly   289 GLEPQRLVVGLPTYGHSFTLVNPLNHRIGAPASGYGKCGQLGFTTLTETCECVTKFFKPNLSYDA 353
            |....:||:|:||:|.||||.:. ...:|||.||.|..|:  ||....|           |:| .
Human   248 GAPASKLVMGIPTFGRSFTLASS-ETGVGAPISGPGIPGR--FTKEAGT-----------LAY-Y 297

  Fly   354 ESCS---------------PYLSALQEWISYENQTSIACKANYVKSLNLGGVMVFSLNTDDLKNS 403
            |.|.               ||.:...:|:.|::|.|:..|..|:|...|.|.||::|:.||.:.|
Human   298 EICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGS 362

  Fly   404 -CSIMPNLKYSEKPVFPLTQAIKDIL 428
             |.  .:|:      ||||.||||.|
Human   363 FCG--QDLR------FPLTNAIKDAL 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cht11	NP_572361.1	Glyco_18	68..398	CDD:214753	111/361 (31%)
		GH18_chitinase-like	69..428	CDD:299167	124/391 (32%)
CHI3L1	NP_001267.2	Glyco_18	23..357	CDD:214753	111/361 (31%)
		GH18_chitolectin_chitotriosidase	24..380	CDD:119351	124/391 (32%)
		Chitooligosaccharide binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01258	70..71		0/3 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01258	204..207		1/2 (50%)
		Important for AKT1 activation and IL8 production. /evidence=ECO:0000250	324..338		4/13 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830