Protein Alignment CG14435 and RNF149

DIOPT Version :10

• Sequence 1: NP_572359.2
• Gene: CG14435 / 31628
• FlyBaseID: FBgn0029911
• Length: 303
• Species: Drosophila melanogaster
• Sequence 2: XP_005263977.1
• Gene: RNF149 / 284996
• HGNCID: 23137
• Length: 428
• Species: Homo sapiens
• Alignment Length: 315
• Identity: 66/315 - (20%)
• Similarity: 95/315 - (30%)
• Gaps: 119/315 - (37%)

  Fly    88 RARSL---SSVPDIQQ-QAQQQQQQGSITSSGSSPHSHP-HAAHGHPAVGVTVSVSGNAN----- 142
            |.|:|   |:|.:|:. ..|......|::.||....|.| ..|||  .|||..:..|:..
Human    31 RGRALEWFSAVVNIEYVDPQTNLTVWSVSESGRFGDSSPKEGAHG--LVGVPWAPGGDLEGCAPD 93

  Fly   143 --------------------ANSNSNF----TAAGNNNGSAMQSYMQQRRTLGDSIRDMSMTG-G 182
                                |.....|    ..|...|.||:..|.::|  .|:....||..| |
Human    94 TRFFVPEPGGRGAAPWVALVARGGCTFKDKVLVAARRNASAVVLYNEER--YGNITLPMSHAGTG 156

  Fly   183 SIA-------------ESIALAASATSANGIGR-------------------------------- 202
            :|.             |.:......|...|:|.
Human   157 NIVVIMISYPKGREILELVQKGIPVTMTIGVGTRHVQEFISGQSVVFVAIAFITMMIISLAWLIF 221

  Fly   203 ------VYTATSLPSHIWSFNGIKCPVCNKFVLPDDIECHLVMCLTKPRLSYNEDVLSDAKGECV 261
                  :||.:.:.|.  |.......|..:.:|      |.|        .:.|..:......|.
Human   222 YYIQRFLYTGSQIGSQ--SHRKETKKVIGQLLL------HTV--------KHGEKGIDVDAENCA 270

  Fly   262 ICLEDLSPGDTIARLPCLCIYHKGCIDRWFEVNRSCP-------------EHPGD 303
            :|:|:....|.|..|||..|:|:.|||.|...:|:||             ..|||
Human   271 VCIENFKVKDIIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGEPGD 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14435	NP_572359.2	mRING-CH-C4HC2H_ZNRF2	248..303	CDD:438356	19/67 (28%)
RNF149	XP_005263977.1	PA_GRAIL_like	43..185	CDD:239037	30/145 (21%)
		RING-H2_RNF149	268..315	CDD:438455	17/46 (37%)