Protein Alignment CG14435 and ZNRF2

DIOPT Version :9

• Sequence 1: NP_001162682.2
• Gene: CG14435 / 31628
• FlyBaseID: FBgn0029911
• Length: 303
• Species: Drosophila melanogaster
• Sequence 2: NP_667339.1
• Gene: ZNRF2 / 223082
• HGNCID: 22316
• Length: 242
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 117/310 - (37%)
• Similarity: 147/310 - (47%)
• Gaps: 75/310 - (24%)

  Fly     1 MGQKASTPATSGQQSPRSRTFS-----SSSTGAADSALQQQQHQHSNPGQNRGGNGGGGGGNDTT 60
            ||.|.|.||.:   :.|:|.:|     |||:|.|:                  |..|||||
Human     1 MGAKQSGPAAA---NGRTRAYSGSDLPSSSSGGAN------------------GTAGGGGG---- 40

  Fly    61 GQGFNLLRTLPGLQVYHNQNSTSIDRQRARSLSSVPDIQQQAQQQQQQGSITSSGSSPHSHPHAA 125
                                      .||.:....|.....|.|....|...::.::| :.|.|.
Human    41 --------------------------ARAAAAGRFPAQVPSAHQPSASGGAAAAAAAP-AAPAAP 78

  Fly   126 HGHPAVGVTVSVSGNANANSNSNFTAAGNNNGSAMQSYMQQRRTLGDSIRDMSMTGGSIAESIAL 190
            ......|...||:..|.| :.|.|:...:::|    .|..|     ||:......||...:....
Human    79 RSRSLGGAVGSVASGARA-AQSPFSIPNSSSG----PYGSQ-----DSVHSSPEDGGGGRDRPVG 133

  Fly   191 AASATSANGIGRVYTATSLPSHI--WSFNGIKCPVCNKFVLPDDIECHLVMCLTKPRLSYNEDVL 253
            .:.......||      |||:|:  ..|.|.|||||:|||..|:::.||||||||||::||||||
Human   134 GSPGGPRLVIG------SLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDVL 192

  Fly   254 SDAKGECVICLEDLSPGDTIARLPCLCIYHKGCIDRWFEVNRSCPEHPGD 303
            |...|||.||||:|..|||||||||||||||||||.||||||||||||.|
Human   193 SKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHPSD 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14435	NP_001162682.2	zf-RING_2	258..298	CDD:290367	34/39 (87%)
ZNRF2	NP_667339.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..141		43/201 (21%)
		zf-RING_2	197..237	CDD:290367	34/39 (87%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152372
Domainoid	1	1.000	86	1.000	Domainoid score	I8133
eggNOG	1	0.900	-	-		E1_KOG0801
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4106
Isobase	1	0.950	-	0	Normalized mean entropy	S1638
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1256682at2759
OrthoFinder	1	1.000	-	-		FOG0001965
OrthoInspector	1	1.000	-	-		otm40343
orthoMCL	1	0.900	-	-		OOG6_105431
Panther	1	1.100	-	-	LDO	PTHR46661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4296
SonicParanoid	1	1.000	-	-		X146
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740