Protein Alignment mAChR-C and TAAR2

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_001028252.1
• Gene: TAAR2 / 9287
• HGNCID: 4514
• Length: 351
• Species: Homo sapiens
• Alignment Length: 355
• Identity: 85/355 - (23%)
• Similarity: 145/355 - (40%)
• Gaps: 71/355 - (20%)

  Fly    14 RSSPE---ALGVVPFLWQHQNATETPTEITLQATSFGAGHLLWLAINAFLFVLILGGNILTIVAV 75
            ||.||   :|||...::                 ||.||.         :|:.|. ||:..|:::
Human    31 RSCPENERSLGVRVAMY-----------------SFMAGS---------IFITIF-GNLAMIISI 68

  Fly    76 RTCRHLRSVISNLFILSLAVSDFCVGLA-LPYHLV------FYMGSDIGAMRGPCLLRFFLLICA 133
            ...:.|.:. :|..|||:|::||.:|.. :||.::      :|.|...      |.:.:...:..
Human    69 SYFKQLHTP-TNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTF------CKIYYSFDLML 126

  Fly   134 CCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPVFWNRWPDA---- 194
            ...|:..|.|:|:||:.|:.|.|.|...:|..|...:::..|.:....|...||...:.|.
Human   127 SITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEGY 191

  Fly   195 ---QACE------FDEVLAPG-YIAGVITPGFVIIWICMFLVYWRIMREASKQALRLRQSVVYNT 249
               .||.      |:::.... ::||..|||.:::.|     |.:|...:.|.|     ..:.|.
Human   192 DILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGI-----YGKIFAVSRKHA-----HAINNL 246

  Fly   250 DEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSLAIANS 314
            .|   .:|..:..|.|:.:.:..::|.|.|||.|.|...:...|....:..:::.........||
Human   247 RE---NQNNQVKKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNS 308

  Fly   315 ALNPIIYSWKNSGFRRAFVQTLCCRTARQC 344
            ..||:||.:....||||....|..:....|
Human   309 TCNPLIYGFFYPWFRRALKYILLGKIFSSC 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	68/292 (23%)
		TM helix 1	53..78	CDD:410626	5/24 (21%)
		TM helix 2	86..111	CDD:410626	10/31 (32%)
		TM helix 3	123..153	CDD:410626	8/29 (28%)
		TM helix 4	166..185	CDD:410626	3/18 (17%)
		TM helix 5	204..229	CDD:410626	7/25 (28%)
		TM helix 6	261..291	CDD:410626	9/29 (31%)
		TM helix 7	300..325	CDD:410626	6/24 (25%)
TAAR2	NP_001028252.1	7tmA_TAAR2_3_4	44..326	CDD:320437	75/328 (23%)
		TM helix 1	45..71	CDD:320437	9/52 (17%)
		TM helix 2	78..104	CDD:320437	10/25 (40%)
		TM helix 3	116..146	CDD:320437	8/29 (28%)
		TM helix 4	158..181	CDD:320437	4/22 (18%)
		TM helix 5	206..235	CDD:320437	8/33 (24%)
		TM helix 6	255..285	CDD:320437	9/29 (31%)
		TM helix 7	294..319	CDD:320437	6/24 (25%)