Protein Alignment mAChR-C and TAAR5

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_003958.2
• Gene: TAAR5 / 9038
• HGNCID: 30236
• Length: 337
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 82/350 - (23%)
• Similarity: 137/350 - (39%)
• Gaps: 79/350 - (22%)

  Fly    30 QNATETPTEITLQAT--------SFGAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVIS 86
            |.|.|.|.....|..        :.|...:::||..|.:.:::| ||:....||...:.|.:. :
Human     7 QGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVL-GNVFVAFAVSYFKALHTP-T 69

  Fly    87 NLFILSLAVSDFCVG-LALPYHLV------FYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISI 144
            |..:||||::|..:| |.||...:      ::.|..:      |.|..:|....|..|:..|..|
Human    70 NFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFL------CRLHTYLDTLFCLTSIFHLCFI 128

  Fly   145 AVDRYIAVVYALHYRRYMTRRVAYSIIIFNW----------------------------CLGALV 181
            ::||:.|:...|.|....|.|||...|:..|                            |:|:..
Human   129 SIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQWLEEMPCVGSCQ 193

  Fly   182 ALLPVFWNRWPDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREASKQALRLRQSVV 246
            .||..||. |                   :..|.|.:..:.|..:|.:|...|::||.::
Human   194 LLLNKFWG-W-------------------LNFPLFFVPCLIMISLYVKIFVVATRQAQQI----- 233

  Fly   247 YNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSLAI 311
              |..:.::.....| :.|:.:.:...:|.:.|||||:....:........:..:::......|.
Human   234 --TTLSKSLAGAAKH-ERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAY 295

  Fly   312 ANSALNPIIYSWKNSGFRRAFVQTL 336
            .|||.|||||.:....||:|...||
Human   296 FNSACNPIIYVFSYQWFRKALKLTL 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	71/306 (23%)
		TM helix 1	53..78	CDD:410626	8/24 (33%)
		TM helix 2	86..111	CDD:410626	10/31 (32%)
		TM helix 3	123..153	CDD:410626	10/29 (34%)
		TM helix 4	166..185	CDD:410626	7/46 (15%)
		TM helix 5	204..229	CDD:410626	4/24 (17%)
		TM helix 6	261..291	CDD:410626	8/29 (28%)
		TM helix 7	300..325	CDD:410626	9/24 (38%)
TAAR5	NP_003958.2	7tmA_TAAR5	35..316	CDD:320441	73/316 (23%)
		TM helix 1	36..62	CDD:320441	8/26 (31%)
		TM helix 2	69..95	CDD:320441	10/25 (40%)
		TM helix 3	107..137	CDD:320441	10/29 (34%)
		TM helix 4	149..172	CDD:320441	5/22 (23%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	176..189		0/12 (0%)
		TM helix 5	196..225	CDD:320441	9/48 (19%)
		TM helix 6	245..275	CDD:320441	8/30 (27%)
		TM helix 7	284..309	CDD:320441	9/24 (38%)