DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and TAAR5

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001376456.1	Gene:	TAAR5 / 9038	HGNCID:	30236	Length:	337	Species:	Homo sapiens

Alignment Length:	350	Identity:	82/350 - (23%)
Similarity:	137/350 - (39%)	Gaps:	79/350 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QNATETPTEITLQAT--------SFGAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVIS 86
            |.|.|.|.....|..        :.|...:::||..|.:.:::| ||:....||...:.|.:. :
Human     7 QGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVL-GNVFVAFAVSYFKALHTP-T 69

  Fly    87 NLFILSLAVSDFCVG-LALPYHLV------FYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISI 144
            |..:||||::|..:| |.||...:      ::.|..:      |.|..:|....|..|:..|..|
Human    70 NFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFL------CRLHTYLDTLFCLTSIFHLCFI 128

  Fly   145 AVDRYIAVVYALHYRRYMTRRVAYSIIIFNW----------------------------CLGALV 181
            ::||:.|:...|.|....|.|||...|:..|                            |:|:..
Human   129 SIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQWLEEMPCVGSCQ 193

  Fly   182 ALLPVFWNRWPDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREASKQALRLRQSVV 246
            .||..||. |                   :..|.|.:..:.|..:|.:|...|::||.::
Human   194 LLLNKFWG-W-------------------LNFPLFFVPCLIMISLYVKIFVVATRQAQQI----- 233

  Fly   247 YNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSLAI 311
              |..:.::.....| :.|:.:.:...:|.:.|||||:....:........:..:::......|.
Human   234 --TTLSKSLAGAAKH-ERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAY 295

  Fly   312 ANSALNPIIYSWKNSGFRRAFVQTL 336
            .|||.|||||.:....||:|...||
Human   296 FNSACNPIIYVFSYQWFRKALKLTL 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	70/305 (23%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	65/288 (23%)
TAAR5	NP_001376456.1	7tmA_TAAR5	35..316	CDD:320441	73/316 (23%)
		TM helix 1	37..61	CDD:320441	8/24 (33%)
		TM helix 2	70..92	CDD:320441	10/21 (48%)
		TM helix 3	108..130	CDD:320441	6/21 (29%)
		TM helix 4	153..169	CDD:320441	2/15 (13%)
		TM helix 5	197..220	CDD:320441	6/42 (14%)
		TM helix 6	251..273	CDD:320441	6/21 (29%)
		TM helix 7	284..309	CDD:320441	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010