DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and taar11

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001076546.1	Gene:	taar11 / 794647	ZFINID:	ZDB-GENE-041014-52	Length:	327	Species:	Danio rerio

Alignment Length:	297	Identity:	80/297 - (26%)
Similarity:	134/297 - (45%)	Gaps:	38/297 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 HLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLV---- 109
            :||::    ...:||:.||:..|..:...:.|.:. :|..|||:||||..:| ..:|..::
Zfish    38 YLLFI----IAIILIVFGNLWVICTISFFQQLHTP-TNYLILSMAVSDLLLGSFVMPPSMLRSLE 97

  Fly   110 --FYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIII 172
              :|.|...      |..........|..|:|.|:.|::|||.||....||:..||.||:..:|:
Zfish    98 TCWYFGDFF------CKFHSATDFTLCNASVLHLVFISIDRYYAVCQPFHYQSRMTTRVSVFMIL 156

  Fly   173 FNWC------LGALVALLPVFWNRWPDAQ-ACEFDEVLAPGYIAGVITPGFVIIWICMFLV---Y 227
            .:|.      .|.:.:.|.:...|..:.. ||:...:...|...|| |...|..::.||::   |
Zfish   157 ISWSFSAFFGFGIIFSELKIEKKRTEELHVACKGGCLALHGREIGV-TYSLVFYFLPMFIIVSLY 220

  Fly   228 WRIMREASKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQL 292
            .|:...|.|. :|:..|.. ::..||.|       |.|:.:.:..|:|.|..||.|||...|...
Zfish   221 SRVFIIALKH-VRVINSAA-SSLSATKM-------DLKATKTLAIIIGVFMSCWTPYFMCNIIDP 276

  Fly   293 FSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFR 329
            .......:::|:....:|..|:..||::|::..|.||
Zfish   277 IVNHTIPALLYEVLMWVAYLNAVFNPLVYAFFYSWFR 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	78/286 (27%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	72/270 (27%)
taar11	NP_001076546.1	7tmA_TAAR1	49..313	CDD:320438	74/280 (26%)
		TM helix 2	69..95	CDD:320438	10/25 (40%)
		TM helix 3	107..137	CDD:320438	10/29 (34%)
		TM helix 4	149..172	CDD:320438	5/22 (23%)
		TM helix 5	197..226	CDD:320438	9/29 (31%)
		TM helix 6	245..275	CDD:320438	12/36 (33%)
		TM helix 7	284..309	CDD:320438	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100