DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and Gpr21

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001103024.1	Gene:	Gpr21 / 689917	RGDID:	1586383	Length:	349	Species:	Rattus norvegicus

Alignment Length:	338	Identity:	95/338 - (28%)
Similarity:	141/338 - (41%)	Gaps:	60/338 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLA--LP-YHLVFYM 112
            ||.:.|..||.|||:.|||:.|........|....::.||.::|.:|..||::  :| ..|::|.
  Rat    29 LLEVLIVVFLTVLIISGNIIVIFVFHCAPLLNHHSTSYFIQTMAYADLLVGVSCLVPSLSLLYYP 93

  Fly   113 GSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCL 177
            .....||  .|.:..|::.....:||.:|..|::|||||:...|.|...:|.......|...|..
  Rat    94 LPMEEAM--TCQVFGFIVSVLKSISMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLY 156

  Fly   178 GALVALLPVF--WNRWPDAQACEFDEVLAPGYIAGVI--------TPGFVIIWICMFL------- 225
            ..|| .||.|  |.:              |||...|.        |..:..::|.|.|
  Rat   157 STLV-FLPSFFHWGK--------------PGYHGDVFRWCAESWHTNSYFTLFIVMTLYAPAALI 206

  Fly   226 ---VYWRIMR-------EASKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLC 280
               .|:.|.|       |.|::..|. .|....|.||.|.      ||.:...::..|...|.:.
  Rat   207 VCFTYFNIFRICQQHTKEISERQARF-SSQNGETGEAQTC------PDKRYAMVLFRITSVFYVL 264

  Fly   281 WLPYFCVAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFR---RAFVQTLC--CRT 340
            ||||....:.:..:.|.|....:.||: |||:||..|.||||..||.|:   :...:::|  |.:
  Rat   265 WLPYIIYFLLESSTGCSSRLASFLTTW-LAISNSFCNCIIYSLSNSVFQQGLKGLSESVCTSCAS 328

  Fly   341 ARQCEDQLPADSK 353
            ....:|.....||
  Rat   329 HTTAKDPYTVRSK 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	85/303 (28%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	76/283 (27%)
Gpr21	NP_001103024.1	7tm_classA_rhodopsin-like	31..308	CDD:410626	85/301 (28%)
		TM helix 1	31..55	CDD:410626	10/23 (43%)
		TM helix 2	65..87	CDD:410626	7/21 (33%)
		TM helix 3	103..125	CDD:410626	5/21 (24%)
		TM helix 4	148..164	CDD:410626	5/16 (31%)
		TM helix 5	189..212	CDD:410626	3/22 (14%)
		TM helix 6	251..273	CDD:410626	6/21 (29%)
		TM helix 7	283..308	CDD:410626	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010