Protein Alignment mAChR-C and Htr7

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: XP_038945768.1
• Gene: Htr7 / 65032
• RGDID: 71034
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 398
• Identity: 100/398 - (25%)
• Similarity: 165/398 - (41%)
• Gaps: 81/398 - (20%)

  Fly     4 TSSSSPAWDYRSSPEALGVVPFLWQHQNATETPTEITLQATSFGAGHLLWLAINAFL---FVLIL 65
            |:|.:|.||   :|                  |..::........|.:..:.|.:.|   .:|.:
  Rat    56 TASPAPTWD---AP------------------PDNVSGCGEQINYGRVEKVVIGSILTLITLLTI 99

  Fly    66 GGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLALPYHLVFYMGSDIGAMRGPCLLRFFLL 130
            .||.|.:::|...:.||.. ||..|:|||::|..|.:|:   :.|...:|:  :.|..:...|..
  Rat   100 AGNCLVVISVCFVKKLRQP-SNYLIVSLALADLSVAVAV---MPFVSVTDL--IGGKWIFGHFFC 158

  Fly   131 -------ICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPVF- 187
                   :..|..|::||..|::|||:.:...|.|......:....:|:..|.|.|.:.|.|:|
  Rat   159 NVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG 223

  Fly   188 WNRWPDAQACEFDEVLAP----GYIAGVITPGFVIIWICMFLVYWRIMREASKQALRLR------ 242
            |     ||....|:|...    ||........|.|....|..:|::|.:.|.|.|.:.:
  Rat   224 W-----AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPR 283

  Fly   243 ---QSVV---------YNTDEATTMRNLLLHP---------DWKSVQIVVFIMGCFTLCWLPYFC 286
               :||:         ...:|...:..||.|.         :.|:...:..|:|.||:||||:|.
  Rat   284 VQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFL 348

  Fly   287 VAIAQLFSICQSSS-----MIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCRTARQCED 346
            ::.|:.| ||.:|.     .:.:|...|..|||.:||.||::.|...|..:...|.|: .|....
  Rat   349 LSTARPF-ICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ-YRNINR 411

  Fly   347 QLPADSKH 354
            :|.|...|
  Rat   412 KLSAAGMH 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	84/318 (26%)
		TM helix 1	53..78	CDD:410626	7/27 (26%)
		TM helix 2	86..111	CDD:410626	9/24 (38%)
		TM helix 3	123..153	CDD:410626	9/36 (25%)
		TM helix 4	166..185	CDD:410626	5/18 (28%)
		TM helix 5	204..229	CDD:410626	6/28 (21%)
		TM helix 6	261..291	CDD:410626	11/38 (29%)
		TM helix 7	300..325	CDD:410626	9/29 (31%)
Htr7	XP_038945768.1	7tmA_5-HT7	100..398	CDD:320452	83/309 (27%)
		TM helix 2	119..145	CDD:320452	10/28 (36%)
		TM helix 3	158..188	CDD:320452	8/29 (28%)
		TM helix 4	200..222	CDD:320452	6/21 (29%)
		TM helix 5	239..268	CDD:320452	7/28 (25%)
		TM helix 6	323..353	CDD:320452	10/29 (34%)
		TM helix 7	366..391	CDD:320452	9/24 (38%)