Protein Alignment mAChR-C and adora2b

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_001034902.1
• Gene: adora2b / 560100
• ZFINID: ZDB-GENE-060511-1
• Length: 351
• Species: Danio rerio
• Alignment Length: 364
• Identity: 108/364 - (29%)
• Similarity: 161/364 - (44%)
• Gaps: 82/364 - (22%)

  Fly    52 LWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLVFYMG-- 113
            |::||...:.||.:.||:|...||.....|::. :|.|::||||:|..|| ||:|:.:...:|
Zfish     4 LYIAIELVIAVLSIAGNVLVCWAVAINSTLKNA-TNYFLVSLAVADILVGCLAIPFAITISIGLW 67

  Fly   114 SDIGAMRGPCLLRFFLLICACCVSMLT------LISIAVDRYIAVVYALHYRRYMTRRVAYSIII 172
            ||.          :..|..||.|.:||      |:::|:|||:||...|.||..:|.:.|..||.
Zfish    68 SDF----------YGCLFLACFVLVLTQSSIFSLLAVAIDRYLAVKIPLRYRELVTGKRAREIIT 122

  Fly   173 FNWCLGALVALLP-VFWNRW-------------------PDAQ------------ACEFDEVLAP 205
            ..|.|..::.|:| |.|||.                   .||.            .|.|::|:..
Zfish   123 ILWILSFIIGLIPFVGWNRKDLACSRNKSGSLQTSNSSDDDAAETETGFLQSCYLECFFEKVVDM 187

  Fly   206 GYIA-----GVITPGFVIIWICMFLVYWRIMREASKQALRLRQ-SVVYNTDEATTMRNLLLHPDW 264
            .|:.     |.:.|..:|    |..:|.:|...|.||   ||| .:..:........:.||..:.
Zfish   188 SYMVYFNFFGCVLPPLLI----MLGIYAKIFTVARKQ---LRQIELKCSVSNGENQHHGLLQREI 245

  Fly   265 KSVQIVVFIMGCFTLCWLPYFCVAIAQLF-SICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGF 328
            ::.:.:..|:|.|.|||||...:....|| |..:..|.|......|:.||||:|||||:::...|
Zfish   246 RAAKSLSIIVGLFALCWLPVHILNCLTLFYSELKKPSFIMNIAIILSHANSAVNPIIYAYRIREF 310

  Fly   329 RRAFVQ-----TLCCRTARQCEDQLPADSKHRMEATSSS 362
            |..|.:     .||.|           |..:|....|||
Zfish   311 RVTFRKILNRHILCQR-----------DELYRSSNGSSS 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	96/319 (30%)
		TM helix 1	53..78	CDD:410626	9/24 (38%)
		TM helix 2	86..111	CDD:410626	12/25 (48%)
		TM helix 3	123..153	CDD:410626	12/35 (34%)
		TM helix 4	166..185	CDD:410626	6/18 (33%)
		TM helix 5	204..229	CDD:410626	6/29 (21%)
		TM helix 6	261..291	CDD:410626	8/29 (28%)
		TM helix 7	300..325	CDD:410626	12/24 (50%)
adora2b	NP_001034902.1	7tm_GPCRs	3..314	CDD:475119	99/327 (30%)
		TM helix 1	5..29	CDD:410628	9/23 (39%)
		TM helix 2	38..60	CDD:410628	12/21 (57%)
		TM helix 3	74..96	CDD:410628	7/21 (33%)
		TM helix 4	119..135	CDD:410628	5/15 (33%)
		TM helix 5	188..211	CDD:410628	5/26 (19%)
		TM helix 6	248..270	CDD:410628	8/21 (38%)
		TM helix 7	282..307	CDD:410628	12/24 (50%)