Protein Alignment mAChR-C and 5-HT1B

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 532
• Identity: 98/532 - (18%)
• Similarity: 151/532 - (28%)
• Gaps: 251/532 - (47%)

  Fly    53 WLAINAFLFVLILG--------GNILTIVAVRTCRHLRSVISNLFILSLAVSD-FCVGLALPYHL 108
            ||.:......::||        ||:..|.|:...|:|::| :|..:.||||:| |...|.:|...
  Fly    85 WLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNV-ANYLVASLAVADLFVACLVMPLGA 148

  Fly   109 VFYMGSDIGAMRGPCLLRFFL---LICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSI 170
            |:.:.:  |.:.||.|...:.   ::| |..|:|.|::||.|||..|. .:.|....|.|..:.:
  Fly   149 VYEISN--GWILGPELCDIWTSCDVLC-CTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLM 209

  Fly   171 IIFNWCLGALVALLPVFWNRWPD------AQACEFDEVLAPGY-IAGVITPGFVIIWICMFLVYW 228
            |...|....:|:|.|.|..:.||      .|.|...:.:  || |.......:|.:.:.:|| ||
  Fly   210 IFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDV--GYQIFATCCTFYVPLLVILFL-YW 271

  Fly   229 --------RIMREASK------------------------------------------------- 236
                    ||.|.|.|
  Fly   272 KIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQL 336

  Fly   237 -QALRLRQSVVY----------------------------------------------------- 247
             :..|.|..:.:
  Fly   337 QRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGT 401

  Fly   248 ---------------NTDEATTMRNLLLHP----------------------------------- 262
                           |.:|..|:...:.|.
  Fly   402 ELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSE 466

  Fly   263 --------------------------------------------------------------DWK 265
                                                                          :.|
  Fly   467 KALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERK 531

  Fly   266 SVQIVVFIMGCFTLCWLPYFCVAIA-QLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFR 329
            :.|.:..|.|.|.:||||:|.:|:. .|...|:..:.:......|...||.|||:||:..|..||
  Fly   532 AAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFR 596

  Fly   330 RAFVQTLCCRTA 341
            |||.:.|..|.|
  Fly   597 RAFKRILFGRKA 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	89/514 (17%)
		TM helix 1	53..78	CDD:410626	8/32 (25%)
		TM helix 2	86..111	CDD:410626	10/25 (40%)
		TM helix 3	123..153	CDD:410626	11/32 (34%)
		TM helix 4	166..185	CDD:410626	4/18 (22%)
		TM helix 5	204..229	CDD:410626	8/33 (24%)
		TM helix 6	261..291	CDD:410626	12/127 (9%)
		TM helix 7	300..325	CDD:410626	8/24 (33%)
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	6/25 (24%)
		TM helix 2	125..151	CDD:320454	10/25 (40%)
		TM helix 3	163..193	CDD:320454	10/30 (33%)
		TM helix 4	204..226	CDD:320454	6/21 (29%)
		TM helix 5	247..276	CDD:320454	8/31 (26%)
		7tm_GPCRs	<525..599	CDD:475119	25/73 (34%)
		TM helix 6	533..555	CDD:410628	9/21 (43%)
		TM helix 7	567..592	CDD:410628	8/24 (33%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	59/203 (29%)