Protein Alignment mAChR-C and HTR4

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_001035263.1
• Gene: HTR4 / 3360
• HGNCID: 5299
• Length: 428
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 97/330 - (29%)
• Similarity: 153/330 - (46%)
• Gaps: 43/330 - (13%)

  Fly    47 GAGHLLWLAINAFLFVLILG---GNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYH 107
            |.|.:..:.:..||..:||.   ||:|.:|||...|.||.:.:|.||:|||.:|..|. |.:|:.
Human    13 GFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFG 77

  Fly   108 LVFYMGSDI---GAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAV-VYALHYRRYMT-RRVA 167
            .: .:..||   |.:.  ||:|..|.:.....|:..|..|::|||.|: ...|.||..|| .|:|
Human    78 AI-ELVQDIWIYGEVF--CLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIA 139

  Fly   168 YSIIIFNWCLGALVALLPVF--W--------------NRWPDAQACEFDEVLAPGYIAGVITPGF 216
            . ::...|.:...::.||:.  |              |:..::..|.|  ::...|........|
Human   140 L-MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVF--MVNKPYAITCSVVAF 201

  Fly   217 VIIWICMFLVYWRIMREASKQALRLR---------QSVVYNTDEATTMRNLLLHPDWKSVQIVVF 272
            .|.::.|.|.|:||...|.:.|.:::         :|...:.|:.:|.|   :..:.|:.:.:..
Human   202 YIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHR---MRTETKAAKTLCI 263

  Fly   273 IMGCFTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLC 337
            |||||.|||.|:|...|...|........::.....|...||.|||.:|::.|..|||||:..||
Human   264 IMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328

  Fly   338 CRTAR 342
            |...|
Human   329 CDDER 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	85/305 (28%)
		TM helix 1	53..78	CDD:410626	10/27 (37%)
		TM helix 2	86..111	CDD:410626	10/25 (40%)
		TM helix 3	123..153	CDD:410626	11/30 (37%)
		TM helix 4	166..185	CDD:410626	2/18 (11%)
		TM helix 5	204..229	CDD:410626	6/24 (25%)
		TM helix 6	261..291	CDD:410626	12/29 (41%)
		TM helix 7	300..325	CDD:410626	7/24 (29%)
HTR4	NP_001035263.1	7tmA_5-HT4	20..323	CDD:320184	89/311 (29%)
		TM helix 1	21..47	CDD:320184	10/25 (40%)
		TM helix 2	55..81	CDD:320184	10/26 (38%)
		TM helix 3	93..123	CDD:320184	11/29 (38%)
		TM helix 4	136..159	CDD:320184	5/23 (22%)
		TM helix 5	189..218	CDD:320184	8/28 (29%)
		TM helix 6	252..282	CDD:320184	12/29 (41%)
		TM helix 7	291..316	CDD:320184	7/24 (29%)