Protein Alignment mAChR-C and HTR1F

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_000857.1
• Gene: HTR1F / 3355
• HGNCID: 5292
• Length: 366
• Species: Homo sapiens
• Alignment Length: 380
• Identity: 94/380 - (24%)
• Similarity: 155/380 - (40%)
• Gaps: 93/380 - (24%)

  Fly    30 QNAT------ETPTEITLQATSFGAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNL 88
            ||.|      ..|::|.:..|..|.. |:...||:.:        |..|:..|...|    .:|.
Human     9 QNLTSEELLNRMPSKILVSLTLSGLA-LMTTTINSLV--------IAAIIVTRKLHH----PANY 60

  Fly    89 FILSLAVSDFCVG-LALPYHLVF------YMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAV 146
            .|.||||:||.|. |.:|:.:|:      .||..:      |.:...:.|..|..|:|.|.:||:
Human    61 LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVV------CDIWLSVDITCCTCSILHLSAIAL 119

  Fly   147 DRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPVFWNRWPDAQACEFDE--VLAPGYIA 209
            |||.|:..|:.|.|..|.:.|..:|...|.:...:::.|:||..    |....|:  ::...:|.
Human   120 DRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRH----QGTSRDDECIIKHDHIV 180

  Fly   210 GVITPGFVIIWICMFLV---YWRIMREA-----SKQALRLRQ-----SVVYNTDEATT------- 254
            ..|...|...:|.:.|:   |::|.|.|     .:||.|:.:     .|:..:.|.:|
Human   181 STIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSY 245

  Fly   255 ----------------------MRNLLLH-PDW-----------KSVQIVVFIMGCFTLCWLPYF 285
                                  :|:...| ..|           |:...:..|:|.|.:||||:|
Human   246 VLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFF 310

  Fly   286 C-VAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCR 339
            . ..:..:...|:.|..:......|...||.:||:||:..|..|::||.:.:.||
Human   311 VKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	80/335 (24%)
		TM helix 1	53..78	CDD:410626	5/24 (21%)
		TM helix 2	86..111	CDD:410626	12/31 (39%)
		TM helix 3	123..153	CDD:410626	12/29 (41%)
		TM helix 4	166..185	CDD:410626	3/18 (17%)
		TM helix 5	204..229	CDD:410626	6/27 (22%)
		TM helix 6	261..291	CDD:410626	11/42 (26%)
		TM helix 7	300..325	CDD:410626	7/24 (29%)
HTR1F	NP_000857.1	7tmA_5-HT1F	24..359	CDD:320456	87/357 (24%)
		TM helix 1	25..51	CDD:320456	7/34 (21%)
		TM helix 2	58..84	CDD:320456	12/25 (48%)
		TM helix 3	96..126	CDD:320456	12/29 (41%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	4/21 (19%)
		TM helix 5	178..207	CDD:320456	7/28 (25%)
		TM helix 6	286..316	CDD:320456	9/29 (31%)
		TM helix 7	326..351	CDD:320456	7/24 (29%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)