Protein Alignment mAChR-C and HTR1E

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_000856.1
• Gene: HTR1E / 3354
• HGNCID: 5291
• Length: 365
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 87/330 - (26%)
• Similarity: 138/330 - (41%)
• Gaps: 65/330 - (19%)

  Fly    68 NILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLVFYMGSD---IGAMRGPCLLRFF 128
            |:..|:|:.|.:.|... :|..|.||||:|..|. |.:|..:: |:..|   :|.......|...
Human    40 NLAVIMAIGTTKKLHQP-ANYLICSLAVTDLLVAVLVMPLSII-YIVMDRWKLGYFLCEVWLSVD 102

  Fly   129 LLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPVFWNRW-- 191
            :..|.|  |:|.|..||:|||.|:..|:.|.|..|.:.|..:|:..|.:...:::.|:||...
Human   103 MTCCTC--SILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRR 165

  Fly   192 --PDAQAC--EFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREA------------------ 234
              |....|  :.|.|:   |........|.|....:.::|:||...|
Human   166 LSPPPSQCTIQHDHVI---YTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRST 227

  Fly   235 ----SKQALRLRQSVV---YNTDEATT-------------MRNLLLHP----------DWKSVQI 269
                |..:.:|.|:..   ::|.:.||             ..|.|.||          :.|:.:|
Human   228 DSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARI 292

  Fly   270 VVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQ 334
            :..|:|.|.|.|||:|...:....||...||.:......|...||.:||::|:..|..|:.||.:
Human   293 LGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKK 357

  Fly   335 TLCCR 339
            .:.||
Human   358 LIRCR 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	81/314 (26%)
		TM helix 1	53..78	CDD:410626	3/9 (33%)
		TM helix 2	86..111	CDD:410626	10/25 (40%)
		TM helix 3	123..153	CDD:410626	12/29 (41%)
		TM helix 4	166..185	CDD:410626	3/18 (17%)
		TM helix 5	204..229	CDD:410626	4/24 (17%)
		TM helix 6	261..291	CDD:410626	12/39 (31%)
		TM helix 7	300..325	CDD:410626	7/24 (29%)
HTR1E	NP_000856.1	7tmA_5-HT1E	23..355	CDD:320457	83/321 (26%)
		TM helix 1	24..50	CDD:320457	3/9 (33%)
		TM helix 2	57..83	CDD:320457	10/26 (38%)
		TM helix 3	95..125	CDD:320457	12/31 (39%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	119..121		1/1 (100%)
		TM helix 4	137..159	CDD:320457	4/21 (19%)
		TM helix 5	179..208	CDD:320457	7/31 (23%)
		TM helix 6	284..314	CDD:320457	10/29 (34%)
		TM helix 7	323..348	CDD:320457	7/24 (29%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	340..344		2/3 (67%)