Protein Alignment mAChR-C and HTR1D

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 102/386 - (26%)
• Similarity: 156/386 - (40%)
• Gaps: 105/386 - (27%)

  Fly    31 NATET-----PTEITLQATSFGAGHLLWLAINAFLFVLILG---GNILTIVAVRTCRHLRSVISN 87
            |||||     |.  ||||        |.:::...|.|:.|.   .|...:..:...|.|.:. :|
Human    21 NATETSEAWDPR--TLQA--------LKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTP-AN 74

  Fly    88 LFILSLAVSDFCVG-LALPYHLVF---------------YMGSDIGAMRGPCLLRFFLLICACC- 135
            ..|.|||.:|..|. |.:|..:.:               ::.|||                .||
Human    75 YLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDI----------------TCCT 123

  Fly   136 VSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPVFWNRWPDAQACEFD 200
            .|:|.|..||:|||.|:..||.|.:..|...|.::|...|.:...:::.|:|| |...||....|
Human   124 ASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFW-RQAKAQEEMSD 187

  Fly   201 EVLAPGYIAGVI--TPG-FVIIWICMFLVYWRIMREASKQALR---------------------- 240
            .::....|:..|  |.| |.|..:.:.::|.||.|.|..:.|.
Human   188 CLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSS 252

  Fly   241 ---LRQS------------VVYN------TDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPY 284
               |..|            :.:|      .|.|...:.:....:.|:.:|:..|:|.|.:||||:
Human   253 LCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPF 317

  Fly   285 FCVAIAQLFSICQSSSMIYKTTFS----LAIANSALNPIIYSWKNSGFRRAFVQTLCCRTA 341
            |.|::  :..||:.|..|:...|.    |...||.:|||||:..|..||:||.:.:..|.|
Human   318 FVVSL--VLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKA 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	84/341 (25%)
		TM helix 1	53..78	CDD:410626	4/27 (15%)
		TM helix 2	86..111	CDD:410626	9/40 (23%)
		TM helix 3	123..153	CDD:410626	11/30 (37%)
		TM helix 4	166..185	CDD:410626	3/18 (17%)
		TM helix 5	204..229	CDD:410626	7/27 (26%)
		TM helix 6	261..291	CDD:410626	11/29 (38%)
		TM helix 7	300..325	CDD:410626	10/28 (36%)
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		1/1 (100%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	90/359 (25%)
		TM helix 1	40..66	CDD:320455	4/25 (16%)
		TM helix 2	73..99	CDD:320455	9/25 (36%)
		TM helix 3	111..141	CDD:320455	14/45 (31%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	4/22 (18%)
		TM helix 5	194..223	CDD:320455	9/28 (32%)
		TM helix 6	294..324	CDD:320455	11/31 (35%)
		TM helix 7	335..360	CDD:320455	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		3/3 (100%)