Protein Alignment mAChR-C and HTR1B

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Alignment Length: 360
• Identity: 86/360 - (23%)
• Similarity: 132/360 - (36%)
• Gaps: 103/360 - (28%)

  Fly    51 LLWLAINAFLFVLI----LGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLV- 109
            |.|..:...|..||    ...|...|..|...|.|.:. :|..|.||||:|..|. |.:|...:
Human    46 LPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTP-ANYLIASLAVTDLLVSILVMPISTMY 109

  Fly   110 --------------FYMGSDIGAMRGPCLLRFFLLICACC-VSMLTLISIAVDRYIAVVYALHYR 159
                          |::.|||                .|| .|:|.|..||:|||.|:..|:.|.
Human   110 TVTGRWTLGQVVCDFWLSSDI----------------TCCTASILHLCVIALDRYWAITDAVEYS 158

  Fly   160 RYMTRRVAYSIIIFNWCLGALVALLPVFWNRWPDAQACE--------FDEVLAPGYIAGVITPGF 216
            ...|.:.|..:|...|.....::|.|.||.:   |:|.|        .|.:|   |........|
Human   159 AKRTPKRAAVMIALVWVFSISISLPPFFWRQ---AKAEEEVSECVVNTDHIL---YTVYSTVGAF 217

  Fly   217 VIIWICMFLVYWRIMREASKQALR----------------------------------------- 240
            ....:.:..:|.||..||..:.|:
Human   218 YFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESG 282

  Fly   241 ----LRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSM 301
                :.|..|..:|.....:.|:...:.|:.:.:..|:|.|.:||||:|.:::  :..||:.:..
Human   283 SPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISL--VMPICKDACW 345

  Fly   302 IYKTTFS----LAIANSALNPIIYSWKNSGFRRAF 332
            .:...|.    |...||.:|||||:..|..|::||
Human   346 FHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	81/349 (23%)
		TM helix 1	53..78	CDD:410626	7/28 (25%)
		TM helix 2	86..111	CDD:410626	10/40 (25%)
		TM helix 3	123..153	CDD:410626	11/30 (37%)
		TM helix 4	166..185	CDD:410626	4/18 (22%)
		TM helix 5	204..229	CDD:410626	3/24 (13%)
		TM helix 6	261..291	CDD:410626	9/29 (31%)
		TM helix 7	300..325	CDD:410626	9/28 (32%)
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	84/358 (23%)
		TM helix 1	51..77	CDD:320455	6/25 (24%)
		TM helix 2	84..110	CDD:320455	10/25 (40%)
		TM helix 3	122..152	CDD:320455	15/45 (33%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	5/22 (23%)
		TM helix 5	205..234	CDD:320455	6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		0/21 (0%)
		TM helix 6	307..337	CDD:320455	9/31 (29%)
		TM helix 7	348..373	CDD:320455	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		3/3 (100%)